Evidence map›Paper›PMID 37387538›Full record

ArticleAging2023

Exploration of the effect of PUM1/Cripto-1 pathway on ferroptosis by regulating macrophage polarization in allogeneic blood transfused mice.

Man-Di Wu, Yan Zhang, Huan Wang, Ke Yue, Yu Bai, Lai-Wei You, Ying-Hui Cui, Jian-Rong Guo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Man-Di WuSchool of Clinic Medicine, Ningxia Medical University, Ningxia 750004, China.
Yan ZhangSchool of Clinic Medicine, Ningxia Medical University, Ningxia 750004, China.
Huan WangSchool of Clinic Medicine, Ningxia Medical University, Ningxia 750004, China.
Ke YueSchool of Medicine, Shanghai University, Shanghai 200444, China.
Yu BaiDepartment of Anesthesiology, Shanghai Gongli Hospital, Naval Military Medical University, Shanghai 200135, China.
Lai-Wei YouDepartment of Anesthesiology, Shanghai Gongli Hospital, Naval Military Medical University, Shanghai 200135, China.
Ying-Hui CuiDepartment of Anesthesiology, Shanghai Gongli Hospital, Naval Military Medical University, Shanghai 200135, China.
Jian-Rong GuoDepartment of Anesthesiology, Shanghai Gongli Hospital, Naval Military Medical University, Shanghai 200135, China.
Second Military Medical University · CNShanghai Pudong New Area Gongli Hospital · CNShanghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo study the link between macrophage polarization, PUM1/Cripto-1 pathway and ferroptosis in the allogeneic blood transfusion setting.

methodsThis is an exploratory research. The purpose of this study was to investigate the effect of PUM1/Cripto-1 pathway on ferroptosis by regulating macrophage polarization in allogeneic blood transfused mice. Establish

resultsIn animal experiments, expression of Cripto-1 was negatively regulated by PUM1 and promoted M1 type polarization of macrophages. Allogeneic blood transfusion assured good state of macrophage mitochondria. Allogeneic blood transfusion inhibited ferroptosis in macrophages by affecting the PUM1/Cripto-1 pathway. In cell experiments, PUM1 regulated Cripto-1 in mouse macrophage RAW264.7. Polarization of RAW264.7 cells was regulated by the PUM1/Cripto-1 pathway. The effect of PUM1/Cripto-1 pathway on macrophage ferroptosis in cell experiments was consistent with that in animal experiments.

conclusionsIn this study, through

Indexed as

FerroptosisHematopoietic Stem Cell TransplantationAnimalsBlood TransfusionIntercellular Signaling Peptides and ProteinsMacrophagesMiceRatsRAW 264.7 CellsIntercellular Signaling Peptides and Proteinsallogeneic blood transfusionmacrophage polarizationPUM1/Cripto-1 pathway

Identifiers

PMID37387538
PMCPMC10333072
OpenAlexW4382631474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.