Evidence map›Paper›PMID 37387262›Full record

ArticleJournal of clinical laboratory analysis2023

RETN gene polymorphisms interact with alcohol dependence in association with depression.

Xiaoyan Xu, Zeping Xu, Fan Zhou, Lijing Chen, Huai Li, Michelle Niculescu, Guanghui Shen, Liujun Wu, Wei Wang, Li Chen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Xiaoyan XuHuzhou Third People's Hospital, Zhejiang, China.
Zeping XuDepartment of Pharmacy, Ningbo Medical Treatment Center, Li Huili Hospital, Ningbo, China.ORCID https://orcid.org/0000-0002-5703-4194
Fan ZhouDepartment of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Lijing ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Huai LiSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Michelle NiculescuDepartment of Social Sciences, Chatham University, Pittsburgh, Pennsylvania, USA.
Guanghui ShenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Liujun WuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Wei WangSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Li ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Yanlong LiuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Jue HeSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Fan WangBeijing Hui-Long-Guan Hospital, Peking University, Beijing, China.
Fan YangThe Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CNChatham University · USNingbo Medical Center Lihuili Hospital · CNNingbo University · CNPeking University · CNThird People's Hospital of Huzhou · CN

Funding

Natural Science Foundation of Xinjiang Province 2018D01C228Natural Science Foundation of Xinjiang Province 2018D01C239The Technology Support Project of Xinjiang 2017E0267
6 · The paper itself

Abstract

backgroundPrevious studies suggest that alcohol dependence is associated with increased risk of depression. The occurrence of depressive symptoms is related to polymorphisms in various genetic regions. This study aimed to investigate the interaction of RETN gene polymorphisms (rs1477341, rs3745368) with alcohol dependence on depressive symptoms in adult male during acute alcohol withdrawal.

methodsA total of 429 male adults were recruited in this study. Alcohol dependence was assessed using the Michigan alcoholism screening test (MAST). Depression was assessed using the 20-item self-rating depression scale (SDS). Hierarchical regression analysis was used to evaluate the interaction between genes and alcohol dependence on depression. Region of significance (ROS) test was used to explain the interaction effect. The strong and weak forms of the differential susceptibility and diathesis models were used to determine which fits the data better.

resultsOur results showed that MAST scores were significantly positively associated with SDS scores (r = 0.23, p < 0.01) in alcohol-dependent patients during alcohol withdrawal. The interaction between genotype and alcohol dependence was significant (β = -0.14, p < 0.05) in a strong diathesis-stress model. Susceptibility for depression symptoms was associated with alcohol dependence in RETN rs1477341 A carriers. Specifically, those that showed more alcohol dependence and the A allele of RETN rs1477341 exhibited more depression symptoms. However, RETN rs3745368 had no significant interaction with alcohol dependence.

conclusionsThe A allele of RETN rs1477341 may correlate with susceptibility to depression symptoms in alcohol-dependent individuals during acute alcohol withdrawal.

Indexed as

AlcoholismSubstance Withdrawal SyndromeAdultDepressionDisease SusceptibilityGenotypeHumansMalePolymorphism, GeneticPolymorphism, Single NucleotideResistinResistinRETN protein, humanalcohol dependencedepressionMichigan alcoholism screening testRETN gene polymorphismsself-rating depression scale

Identifiers

PMID37387262
PMCPMC10431411
OpenAlexW4382631083

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.