Evidence map›Paper›PMID 37386823›Full record

ArticleStatistical methods in medical research2023

Economizing comparative Poisson clinical trials of multiple experimental treatments by testing against the same control.

Joseph A Chiarappa, Donald R Hoover, Alison Pedley

Open access · greenAbstract read
In one paragraph

Article in Statistical methods in medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joseph A ChiarappaMerck and Co. Inc., North Wales, PA, USA.ORCID 0000-0002-1167-0259
Donald R HooverDepartment of Statistics and the Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, NJ, USA.
Alison PedleyMerck and Co. Inc., North Wales, PA, USA.
Merck & Co., Inc., Rahway, NJ, USA (United States) · USRutgers, The State University of New Jersey · US

Funding

Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
"Enhancing Cancer Research in Central Africa IeDEA"U01AI096299 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Denis Nash, Marcel Yotebieng · 2011 to 2026
$35.8M
Reducing urban women's HIV risk: Soap opera videos streamed to mobile devicesR01NR014632 · NINR · NORTHEASTERN UNIVERSITY · PI JONES, RACHEL · 2015 to 2018
$2.0M
NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI096299NINR NIH HHS R01 NR014632
6 · The paper itself

Abstract

Comparative Poisson trials of an experimental treatment versus a control typically condition on the total number of events that occur across both arms (Design A). Inference is based on the binomial distribution. Recently, an approach termed Design C to compare

Indexed as

Research DesignTherapies, InvestigationalHumansSample Sizeclinical trialsComparative Poissonexpected follow-upsample sizetreatment superiority

Identifiers

PMID37386823
PMCPMC10977049
OpenAlexW4382631577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.