ReviewJournal of anesthesia, analgesia and critical care2022
Spinal anesthesia and hypotensive events in hip fracture surgical repair in elderly patients: a meta-analysis.
Review in Journal of anesthesia, analgesia and critical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of hemodynamic and anaesthetic outcomes between height-based and conventional spinal anaesthetic dosing in geriatric patients undergoing lower limb orthopaedic surgeries
Comparison of Preoperative Pericapsular Nerve Group (PENG) Block Versus Femoral Nerve Block for Optimizing Spinal Anaesthesia in Proximal Femur Fracture Surgery: A Prospective Randomized Controlled Trial
Who cites it
28 citing papers in PubMed.
- Impact of bupivacaine dose on haemodynamics in elderly hip surgery: a randomized controlled trial.BMC geriatrics · 2026Trial
- Leg compression for preventing hypotension after spinal anesthesia in elderly hip fracture patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Trial
- Comparison of the effects of two different local anesthetics used in spinal anesthesia on peripheral and central temperature change: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Opioid-Free Anesthesia with Esketamine Combined with Iliac Fascia Block in Elderly Patients Undergoing Hip Surgery.Drug design, development and therapy · 2025Trial
- Comparison of hypotension between propofol and remimazolam-propofol combinations sedation for day-surgery hysteroscopy: a prospective, randomized, controlled trial.BMC anesthesiology · 2024Trial
- Accessing the efficacy and peri-operative adverse effects of three different hyperbaric bupivacaine 0.5% dosages for spinal anesthesia induction in lower limb orthopedic surgeries: a randomized clinical trial.BMC anesthesiology · 2024Trial
- Trial
- Association Between Immediate Postoperative Pulse Pressure and Three-Year All-Cause Mortality After Hip Fracture Surgery in Older Adults: A Post Hoc Analysis of a Prospective Cohort.Journal of clinical medicine · 2026Article
- Success rate and block characteristics of L5-S1 spinal anesthesia with hypobaric bupivacaine in total hip and knee arthroplasty.Korean journal of anesthesiology · 2026Observational
- A Nomogram for Predicting the Risk of Spinal Anesthesia-Induced Hypotension in Older Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Ultrasound-guided measurement of cross-sectional area of dural sac to titrate the dosage of local anaesthetic in geriatric orthopaedic surgery under spinal anaesthesia: A prospective randomised study.Indian journal of anaesthesia · 2026Article
- Continuous Spinal Anesthesia in a High-Risk Patient With Pulmonary Hypertension Undergoing Hip Fracture Repair: A Case Report.Case reports in anesthesiology · 2026Article
- Low-Dose Subarachnoid Anesthesia Combined with PENG and FLCN Blocks Reduces Hypotensive Episodes Without Compromising Anesthetic Depth and Duration in Hip Fracture Surgery: A Retrospective Observational Study.Medicina (Kaunas, Lithuania) · 2025Observational
- A Retrospective Observational Study of Ephedrine Use in Hip Arthroplasty: Routine Practice at a Secondary Care Hospital in Romania.Clinics and practice · 2025Article
- Perfusion index as a predictor of hypotension after spinal anesthesia in lower extremity orthopedic surgery: a prospective observational trial.BMC surgery · 2025Observational
- Comparison of Anterior and Posterior Surgical Approaches in Total Hip Arthroplasty: Effect on Self-Reported and Functional Outcomes.Journal of clinical medicine · 2025Article
- Patient Controlled Intravenous Analgesia with Oxycodone or Sufentanil After Hip Surgery: Study Protocol for a Multi-Centered, Randomized Controlled Trial.Journal of clinical medicine · 2025Article
- Advances in Managing Pelvic Fractures in Polytrauma: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Epidemiology of Periprosthetic Fractures After Cementless Revision Total Hip Arthroplasty with Tapered, Fluted Stems at a Mid- to Long-Term Follow-Up.Journal of clinical medicine · 2025Article
- Postoperative Patient-Reported Pain and Opioid Consumption After Total Hip Arthroplasty: A Propensity Score-Matched Comparison of the Direct Superior and Posterior Approaches.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpinal anesthesia (SA) is widely used for anesthetic management of patients undergoing hip surgery, and hypotension is the most common cardiovascular side effect of SA. This paper aims to assess the lowest effective dose of SA that reduces the occurrence of intraoperative hypotension in elderly patients scheduled for major lower limb orthopedic surgery.
methodsWe conducted a systematic review of randomized controlled trials (RCTs) performed in elderly patients scheduled for surgical hip repair and a meta-analysis with meta-regression on the occurrence of hypotensive episodes at different effective doses of anesthetics. We searched PUBMED®, EMBASE®, and the Cochrane Controlled Clinical trials registered.
resultsOur search retrieved 2085 titles, and after screening, 6 were finally included in both the qualitative and quantitative analysis, including 344 patients [15% (10-28) males], with a median (25th to 75th interquartile) age of 82 (80-85). The risk of bias assessment reported "low risk" for 5 (83.3%) and "some concerns" for 1 (16.7%) of the included RCTs. The low dose of SA of [mean 6.5 mg (1.9)] anesthetic was associated with a lower incidence of hypotension [OR = 0.09 (95%CI 0.04-0.21); p = 0.04; I
conclusionsIn the included studies of this meta-analysis, a mean dose of 6.5 mg of SA was effective in producing intraoperative comfort and motor block and associated with a lower incidence of hypotension as compared to a mean dose of 10.5 mg.
trial registrationCRD42020193627.
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Registered trials
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