Evidence map›Paper›PMID 37386514›Full record

ArticleAIDS research and therapy2023

Influence of depression and interpersonal support on adherence to antiretroviral therapy among people living with HIV.

Jerry John Nutor, Akua O Gyamerah, Robert Kaba Alhassan, Henry Ofori Duah, Rachel G A Thompson, Natalie Wilson, Orlando Harris, Jose Gutierrez, Thomas J Hoffmann, Monica Getahun and 1 more

Abstract read
In one paragraph

Article in AIDS research and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jerry John NutorDepartment of Family Health Care Nursing, School of Nursing, University of California San Francisco, San Francisco, CA, USA. jerry.nutor@ucsf.edu.
Akua O GyamerahDepartment of Community Health and Health Behavior, University of Buffalo, Buffalo, NY, USA.
Robert Kaba AlhassanCentre for Health Policy and Implementation Research, Institute of Health Research, University of Health and Allied Sciences, Ho, Ghana.
Henry Ofori DuahCollege of Nursing, University of Cincinnati, Cincinnati, OH, USA.
Rachel G A ThompsonLanguage Center, College of Humanities, University of Ghana, Accra, Ghana.
Natalie WilsonDepartment of Community Health Systems, School of Nursing, University of California San Francisco, San Francisco, CA, USA.
Orlando HarrisDepartment of Community Health Systems, School of Nursing, University of California San Francisco, San Francisco, CA, USA.
Jose GutierrezDepartment of Family Health Care Nursing, School of Nursing, University of California San Francisco, San Francisco, CA, USA.
Thomas J HoffmannDepartment of Epidemiology and Biostatistics, Office of Research, School of Nursing, University of California, San Francisco, San Francisco, CA, USA.
Monica GetahunInstitute for Global Health Sciences, University of California, San Francisco, San Francisco, CA, USA.
Glenn-Milo SantosDepartment of Community Health Systems, School of Nursing, University of California San Francisco, San Francisco, CA, USA.

Funding

TRAINEESHIPS IN AIDS PREVENTION STUDIEST32MH019105 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carol Suzanne Camlin, Glenn-Milo Santos · 1989 to 2026
$15.3M
Substance Use and HIV Prevention Research in Minority Communities Training ProgramR25DA028567 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Julia Lechuga, Torsten Brian Neilands · 2009 to 2026
$5.4M
Jamaica CARES Project: Enhancing HIV Care Continuity Among Priority Populations in JamaicaK23MH130250 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Orlando Omar Harris · 2022 to 2026
$998k
NIDA NIH HHS R25 DA028567NIMH NIH HHS K23 MH130250NIMH NIH HHS T32 MH019105
6 · The paper itself

Abstract

backgroundPoor adherence and under-utilization of antiretroviral therapy (ART) services have been major setbacks to achieving 95-95-95 policy goals in Sub-Saharan Africa. Social support and mental health challenges may serve as barriers to accessing and adhering to ART but are under-studied in low-income countries. The purpose of this study was to examine the association of interpersonal support and depression scores with adherence to ART among persons living with HIV (PLWH) in the Volta region of Ghana.

methodsWe conducted a cross-sectional survey among 181 PLWH 18 years or older who receive care at an ART clinic between November 2021 and March 2022. The questionnaire included a 6-item simplified ART adherence scale, the 20-item Center for Epidemiologic Studies Depression Scale (CES-D), and the 12-item Interpersonal Support Evaluation List-12 (ISEL-12). We first used a chi-squared or Fisher's exact test to assess the association between these and additional demographic variables with ART adherence status. We then built a stepwise multivariable logistic regression model to explain ART adherence.

resultsART adherence was 34%. The threshold for depression was met by 23% of participants, but it was not significantly associated with adherence in multivariate analysis(p = 0.25). High social support was reported by 48.1%, and associated with adherence (p = 0.033, aOR = 3.45, 95% CI = 1.09-5.88). Other factors associated with adherence included in the multivariable model included not disclosing HIV status (p = 0.044, aOR = 2.17, 95% CI = 1.03-4.54) and not living in an urban area (p = 0.00037, aOR = 0.24, 95% CI = 0.11-0.52).

conclusionInterpersonal support, rural residence, and not disclosing HIV status were independent predictors of adherence to ART in the study area.

Indexed as

DepressionHIV InfectionsAmbulatory Care FacilitiesAnti-Retroviral AgentsCross-Sectional StudiesHumansSocial SupportAnti-Retroviral AgentsAdherenceAntiretroviral therapyDepressionInterpersonal support

Identifiers

PMID37386514
PMCPMC10308781

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.