Evidence map›Paper›PMID 37386495›Full record

ArticleRadiation oncology (London, England)2023

Proton beam therapy in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus.

Takashi Saito, Masahiro Nakayama, Kayoko Ohnishi, Shuho Tanaka, Masatoshi Nakamura, Motohiro Murakami, Shin Matsumoto, Keiichiro Baba, Keitaro Fujii, Masashi Mizumoto and 2 more

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Article in Radiation oncology (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Takashi SaitoDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Japan. saitoh@pmrc.tsukuba.ac.jp.
Masahiro NakayamaDepartment of Otolaryngology, Head and Neck Surgery, University of Tsukuba, Tsukuba, Japan.
Kayoko OhnishiDepartment of Radiology, School of Medicine, International University of Health and Welfare, Narita, Japan.
Shuho TanakaDepartment of Otolaryngology, Head and Neck Surgery, University of Tsukuba, Tsukuba, Japan.
Masatoshi NakamuraDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
Motohiro MurakamiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
Shin MatsumotoDepartment of Otolaryngology, Head and Neck Surgery, University of Tsukuba, Tsukuba, Japan.
Keiichiro BabaDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
Keitaro FujiiDepartment of Otolaryngology, Head and Neck Surgery, University of Tsukuba, Tsukuba, Japan.
Masashi MizumotoDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.
Keiji TabuchiDepartment of Otolaryngology, Head and Neck Surgery, University of Tsukuba, Tsukuba, Japan.
Hideyuki SakuraiDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate proton beam therapy (PBT) in multimodal treatment for locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinus (NPSCC).

methodsThe cases in this study included T3 and T4 NPSCC without distant metastases that were treated at our center using PBT between July 2003 and December 2020. These cases were classified into 3 groups based on resectability and treatment strategy: surgery followed by postoperative PBT (group A); those indicated to be resectable, but the patient refused surgery and received radical PBT (group B); and those declared unresectable based on the extent of the tumor and treated with radical PBT (group C).

resultsThe study included 37 cases, with 10, 9 and 18 in groups A, B and C, respectively. The median follow-up period in surviving patients was 4.4 years (range 1.0-12.3 years). The 4-year overall survival (OS), progression-free survival (PFS), and local control (LC) rates were 58%, 43% and 58% for all patients; 90%, 70% and 80% in group A, 89%, 78% and 89% in group B; and 24%, 11% and 24% in group C. There were significant differences in OS (p = 0.0028) and PFS (p = 0.009) between groups A and C; and in OS (p = 0.0027), PFS (p = 0.0045) and LC (p = 0.0075) between groups B and C.

conclusionsPBT gave favorable outcomes in multimodal treatment for resectable locally advanced NPSCC, including surgery followed by postoperative PBT and radical PBT with concurrent chemotherapy. The prognosis for unresectable NPSCC was extremely poor, and reconsideration of treatment strategies, such as more active use of induction chemotherapy, may improve outcomes.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsProton TherapyCombined Modality TherapyHumansSquamous Cell Carcinoma of Head and NeckMultimodal treatmentNasal cavityOutcomesParanasal sinusProton beam therapySquamous cell carcinoma

Identifiers

PMID37386495
PMCPMC10311771

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