SynthesisLangenbeck's archives of surgery2023
Anastomotic leak risk factors following colon cancer resection: a systematic review and meta-analysis.
Synthesis in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Meta-analysis ofFrontiers in cellular and infection microbiology · 2025Pooled it
- Is mechanical bowel preparation mandatory for elective colon surgery? A systematic review and meta-analysis.Langenbeck's archives of surgery · 2024Pooled it
- Effect of intraoperative anastomotic reinforcement suture on the prevention of anastomotic leakage of double-stapling anastomosis for laparoscopic rectal cancer: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2023Pooled it
- Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial.World journal of surgery · 2026Trial
- Prevention and management of anastomotic leakage after colorectal resection: evolving trends among Italian surgeons. A SICCR survey.Updates in surgery · 2026Article
- Circular stapler platform and the risk of anastomotic leakage after elective left colectomy and high anterior resection.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Observational
- Article
- Emergency Surgery and the Risk of Anastomotic Leakage After Colorectal Resection with Primary Anastomosis for Benign and Malignant Disease: A Single-Center Retrospective Study.Journal of clinical medicine · 2026Article
- Impact of powered circular stapling devices on anastomotic leakage rates in colorectal surgery.International journal of colorectal disease · 2026Article
- Omentoplasty to Prevent Anastomotic Leak in Colorectal Anastomosis: A Systematic Review and Meta-Analysis.Cureus · 2026Review
- Cumulative Surgeon Experience and Anastomotic Leakage After Left-Sided and Segmental Colorectal Resection with Primary Anastomosis: A Seven-Year Single-Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Postoperative anastomotic leakage after colon cancer surgery may reduce long-term survival.International journal of colorectal disease · 2026Article
- Review
- Quantum machine learning for predicting anastomotic leak: a clinical study.Scientific reports · 2026Article
- Association of preoperative insulin resistance surrogate indices with the risk of anastomotic leakage after colorectal cancer resection: a multicenter retrospective cohort.World journal of surgical oncology · 2026Article
- Midgut Neuroendocrine Tumours: Are They at Higher Risk of Anastomotic Leak Than Midgut Adenocarcinomas? A Case-Control Study.Cancer reports (Hoboken, N.J.) · 2026Article
- Integrated intraoperative strategies to prevent anastomotic leakage after laparoscopic low anterior resection: The roles of left colic artery preservation, reinforcement suturing, and transanal tube placement.The Journal of international medical research · 2026Article
- Risk factor analysis and nomogram model development for anastomotic leakage following laparoscopic radical colorectal cancer surgery.World journal of surgical oncology · 2026Article
- Understanding Anastomotic Healing in Colo-Rectal Surgery; a Multicentric 5-Year Analysis of Predictive Factors for Integrity and Fistula Formation.Diagnostics (Basel, Switzerland) · 2026Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite improved surgical techniques, anastomotic leakage is still a serious complication that can occur after colon cancer resection, resulting in increased morbidity and mortality. The aim of this study was to evaluate the risk factors for anastomotic leakage after colon cancer surgery, provide a theoretical basis for reducing its occurrence, and guide the practice of clinicians.
methodsA systematic review of PubMed, Ovid, Web of Science and Cochrane Central Register of Controlled Trials databases was conducted by using a combination of subject terms and free words for online searches. The databases were searched from their inception to 31 March 2022, and all cross-sectional, cohort or case‒control studies examining the risk factors for the development of anastomotic fistula after surgery for colon cancer were identified.
resultA total of 2133 articles were searched for this study, and 16 publications were ultimately included, all of which were cohort studies. A total of 115,462 subjects were included, and a total of 3959 cases of anastomotic leakage occurred postoperatively, with an incidence of 3.4%. The odds ratio (OR) and 95% confidence interval (CI) were used for evaluation. Male sex (OR = 1.37, 95% CI: 1.29-1.46, P < 0.00001), BMI (OR = 1.04, 95% CI: 1.00-1.08, P = 0.03), diabetes (OR = 2.80, 95% CI: 1.81-4.33, P < 0.00001), combined lung disease (OR = 1.28, 95% CI: 1.15-1.42, P < 0.00001), anaesthesia ASA score (OR = 1.35, 95% CI: 1.24-1.46, P < 0.00001), ASA class ≥ III (OR = 1.34, 95% CI: 1.22-1.47, P < 0.00001), emergency surgery (OR = 1.31, 95% CI: 1.11-1.55, P = 0.001), open surgery (OR = 1.94, 95% CI: 1.69-2.24, P < 0.00001) and type of surgical resection (OR = 1.34, 95% CI: 1.12-1.61, P = 0.002) are risk factors for anastomotic leakage after colon cancer surgery. There is still a lack of strong evidence on whether age (OR = 1.00, 95% CI: 0.99-1.01, P = 0.36) and cardiovascular disease (OR = 1.18, 95% CI: 0.94-1.47, P = 0.16) are factors influencing the occurrence of anastomotic leakage after colon cancer surgery.
conclusionsMale sex, BMI, obesity, coexisting pulmonary disease, anaesthesia ASA score, emergency surgery, open surgery and type of resection were risk factors for anastomotic leakage after colon cancer surgery. The effect of age and cardiovascular disease on postoperative anastomotic leakage in patients with colon cancer needs further study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.