Evidence map›Paper›PMID 37386056›Full record

ArticleScientific reports2023

Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices.

Chengzhang Li, Zhenrong Li, Sihan Xu, Sanwei Jiang, Zhenli Ye, Bin Yu, Shixiang Gong, Junmei Li, Qilin Hu, Bingyan Feng and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chengzhang Li *Henan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Zhenrong Li *Henan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Sihan Xu *Henan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Sanwei JiangHenan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Zhenli YeHenan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Bin YuHenan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Shixiang GongSchool of Information Science and Engineering, Yanshan University, Qinhuangdao, China.
Junmei LiHenan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Qilin HuHenan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Bingyan FengHenan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Mengmeng WangHenan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China.
Chengbiao LuHenan International Key Laboratory for Noninvasive Neuromodulation/Key Laboratory of Brain Research of Henan Province, Department of Physiology & Pathophysiology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China. johnlu9000@xxmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacologically-induced persistent hippocampal γ oscillation in area CA3 requires activation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs). However, we demonstrated that exogenous AMPA dose-dependently inhibited carbachol (CCH)-induced γ oscillation in the CA3 area of rat hippocampal slices, but the underlying mechanism is not clear. Application of AMPARs antagonist NBQX (1 μM) did not affect γ oscillation power (γ power), nor AMPA-mediated γ power reduction. At 3 μM, NBQX had no effect on γ power but largely blocked AMPA-mediated γ power reduction. Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase KinaseHippocampusalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCA3 Region, HippocampalCarbacholPhysical Therapy ModalitiesRatsalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidCalcium-Calmodulin-Dependent Protein Kinase KinaseCarbachol

Identifiers

PMID37386056
PMCPMC10310770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.