ArticleNature communications2023
Inhibition of chitin deacetylases to attenuate plant fungal diseases.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
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- Biosynthesis of Benzohydroxamic Acid inJournal of natural products · 2026Article
- Beyond Fungitoxicity: Recent Achievements in Targeted Fungicide Discovery.Journal of fungi (Basel, Switzerland) · 2026Review
- A Conserved Magnaporthe oryzae Effector Counteracts the Rice Ubiquitin-Proteasome System by Disrupting the E2 Function to Suppress Immunity.Plant biotechnology journal · 2026Article
- Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Inhibition of RNase to Attenuate Fungal-Manipulated Rhizosphere Microbiome and Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bifunctional Phyto-Synthesized Nano Silver for Mitigating Salinity-Induced Dormancy and Associated Fungal Infections During Seed Germination in Brassica juncea with Integration of Machine Learning-Based Predictive Modeling.Applied biochemistry and biotechnology · 2025Article
- Computational studies reveal structural characterization and novel families of Puccinia striiformis f. sp. tritici effectors.PLoS computational biology · 2025Article
- Single-cell transcriptomic profiling of maize cell heterogeneity and systemic immune responses against Puccinia polysora Underw.Plant biotechnology journal · 2025Article
- Phytoconstituent Profiling and Antifungal Efficacy of Artemisia absinthium L.: Towards Sustainable Bio-Fungicide Development.Applied biochemistry and biotechnology · 2025Article
- Powerful cell wall biomass degradation enzymatic system from saprotrophicCell surface (Amsterdam, Netherlands) · 2024Review
- The Win-Win Effects of an Invasive Plant Biochar on a Soil-Crop System: Controlling a Bacterial Soilborne Disease and Stabilizing the Soil Microbial Community Network.Microorganisms · 2024Article
- Host Recognition and Specific Infection ofJournal of fungi (Basel, Switzerland) · 2023Article
- The molecular structure, biological roles, and inhibition of plant pathogenic fungal chitin deacetylases.Frontiers in plant science · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytopathogenic fungi secrete chitin deacetylase (CDA) to escape the host's immunological defense during infection. Here, we showed that the deacetylation activity of CDA toward chitin is essential for fungal virulence. Five crystal structures of two representative and phylogenetically distant phytopathogenic fungal CDAs, VdPDA1 from Verticillium dahliae and Pst_13661 from Puccinia striiformis f. sp. tritici, were obtained in ligand-free and inhibitor-bound forms. These structures suggested that both CDAs have an identical substrate-binding pocket and an Asp-His-His triad for coordinating a transition metal ion. Based on the structural identities, four compounds with a benzohydroxamic acid (BHA) moiety were obtained as phytopathogenic fungal CDA inhibitors. BHA exhibited high effectiveness in attenuating fungal diseases in wheat, soybean, and cotton. Our findings revealed that phytopathogenic fungal CDAs share common structural features, and provided BHA as a lead compound for the design of CDA inhibitors aimed at attenuating crop fungal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.