Evidence map›Paper›PMID 37385978›Full record

ArticleJournal of the International Neuropsychological Society : JINS2024

Sex significantly predicts medial temporal volume when controlling for the influence of ApoE4 biomarker and demographic variables: A cross-ethnic comparison.

Patricia Garcia, Lisandra Mendoza, Dilianna Padron, Andres Duarte, Ranjan Duara, David Loewenstein, Maria Greig-Custo, Warren Barker, Rosie Curiel, Monica Rosselli and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Sex differences inFrontiers in dementia · 2025
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Patricia GarciaDepartment of Clinical Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-7922-8432
Lisandra MendozaBay Pines VA Healthcare System, Bay Pines, FL, USA.
Dilianna PadronAlbizu University-Miami Campus, Miami, FL, USA.
Andres DuarteAlbizu University-Miami Campus, Miami, FL, USA.
Ranjan DuaraMount Sinai Medical Center, Miami Beach, FL, USA.
David LoewensteinUniversity of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Maria Greig-CustoMount Sinai Medical Center, Miami Beach, FL, USA.
Warren BarkerMount Sinai Medical Center, Miami Beach, FL, USA.
Rosie CurielUniversity of Miami Leonard M. Miller School of Medicine, Miami, FL, USA.
Monica RosselliDepartment of Psychology, Florida Atlantic University, Davie, FL, USA.ORCID 0000-0003-2656-9505
Miriam RodriguezDepartment of Health & Wellness Design, Indiana University Bloomington School of Public Health, Bloomington, IN, USA.ORCID 0000-0002-0816-8313
Mount Sinai Medical Center · USCarlos Albizu University · PRUniversity of Miami · USBay Pines VA Healthcare System · USFlorida Atlantic University · USIndiana University Bloomington · USIndiana University School of Medicine

Funding

Social Determinants of Health, Race/Ethnicity, and White Matter HyperintensitiesP30AG066506 · NIA · UNIVERSITY OF FLORIDA · PI Ranjan Duara, DAVID LOEWENSTEIN · 2020 to 2026
$25.6M
University of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI GOLDE, TODD E · 2015 to 2019
$7.3M
NIA NIH HHS P30 AG066506NIA NIH HHS P50 AG047266
6 · The paper itself

Abstract

objectiveTo explore the relationship between age, education, sex, and ApoE4 (+) status to brain volume among a cohort with amnestic mild cognitive impairment (aMCI).

methodOne hundred and twenty-three participants were stratified into Hispanic (

resultsBonferroni-corrected results indicated that when controlling for ApoE4 status, education, and age, sex was a significant predictor of hippocampal volume among the Hispanic group (

conclusionsBiological sex, rather than ApoE4 status, was a greater predictor of hippocampal volume among Hispanic and WNH females. These findings add to the mixed literature on sex differences in dementia research and highlight continued emphasis on ethnic populations to elucidate on neurodegenerative disparities.

Indexed as

Apolipoprotein E4BiomarkersDemographyEntorhinal CortexFemaleHumansMaleNeurodegenerative DiseasesApolipoprotein E4BiomarkersAD biomarkersApoE4cross-cultural neuropsychologycross-cultural researchsex differences in ADwomen and aging

Identifiers

PMID37385978
PMCPMC11057967
OpenAlexW4382515687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.