Evidence map›Paper›PMID 37385877›Full record

ArticleTrends in neurosciences2023

Three players in the 'toxic affair' between botulinum neurotoxin type A and neurons.

Ornella Rossetto, Marco Pirazzini, Cesare Montecucco

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ornella RossettoDepartment of Biomedical Sciences, University of Padova, Padova, Italy; Consiglio Nazionale delle Ricerche, Institute of Neuroscience, University of Padova, Padova, Italy. Electronic address: ornella.rossetto@unipd.it.
Marco PirazziniDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Cesare MontecuccoDepartment of Biomedical Sciences, University of Padova, Padova, Italy; Consiglio Nazionale delle Ricerche, Institute of Neuroscience, University of Padova, Padova, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Joensuu and colleagues have recently shown that botulinum neurotoxin (BoNT) type A exploits a heterotrimeric complex in the presynaptic membrane to bind to and enter neurons using a Trojan horse-like mechanism. Similar processes may be relevant to the neuronal entry of different botulinum toxin serotypes and other neuropathogens.

Indexed as

Botulinum Toxins, Type AMembrane GlycoproteinsNerve Tissue ProteinsNeuronsSynaptic VesiclesBotulinum Toxins, Type AMembrane GlycoproteinsNerve Tissue Proteinsbotulinum toxin type AendocytosispolysialogangliosideSV2synaptic vesiclesynaptotagmin-1

Identifiers

PMID37385877
OpenAlexW4382199456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.