Evidence map›Paper›PMID 37385855›Full record

ArticleBritish journal of anaesthesia2023

Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function.

Jennifer Taylor, Justin G Wu, David Kunkel, Margaret Parker, Cameron Rivera, Cameron Casey, Sharon Naismith, Armando Teixeira-Pinto, Mervyn Maze, Robert A Pearce and 2 more

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01980511 completednot on this map

Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN

TypeobservationalSponsorMcMaster UniversityRan2014 to 2018Enrolled1,116ConditionsCovert Postoperative Stroke
NCT03124303 recruitingnot on this map

Interventions for Postoperative Delirium: Biomarker-3

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2017 to 2029Enrolled468ConditionsDeliriumArmsHigh Density-Electroencephalogram, Magnetic Resonance Imaging, Blood specimen collection, Pupillometry
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jennifer TaylorCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Justin G WuCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
David KunkelDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Margaret ParkerDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Cameron RiveraDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Cameron CaseyDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Sharon NaismithHealthy Brain Ageing Program, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia; School of Psychology, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Armando Teixeira-PintoFaculty of Public Health, The University of Sydney, Sydney, NSW, Australia.
Mervyn MazeDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
Robert A PearceDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Richard LennertzDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Robert D SandersCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, NSW, Australia. Electronic address: robert.sanders@sydney.edu.au.
University of Wisconsin–Madison · USThe University of Sydney · AUUniversity of California, San Francisco · US

Funding

Clarifying the overlapping pathology of delirium and dementiaR01AG063849 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Richard C Lennertz, Robert D Sanders · 2019 to 2026
$5.0M
NIA NIH HHS R01 AG063849
6 · The paper itself

Abstract

backgroundUnresolved surgical inflammation might induce chronic cognitive decline in older adults. Although inflammatory biomarkers have been correlated with perioperative cognitive impairment and delirium, the effects of prolonged inflammation on cognition are not well studied. This prospective cohort study investigated 1-yr dynamics in plasma interleukin-6 levels and executive function.

methodsPatients undergoing major surgery (n=170) aged ≥65 yr completed Trail Making Test B and other neuropsychological assessments with plasma interleukin-6 levels collected on postoperative days 1-9 and 90, and at 1-yr. Mixed-effects analyses were conducted for Trail Making Test B (and other assessments), including interleukin-6 levels, time, and additional confounders (fixed effects), and a random effect for participant.

resultsChanges in interleukin-6 levels were associated with changes in Trail Making Test B over 1 yr in a generalised additive model (β=0.074, P<0.001) supporting that unresolved inflammation impaired executive function. This result was robust to confounders, outlier rejection, and fitting to non-linear models. Changes in interleukin-6 levels also correlated with changes in Trail Making Test A and Controlled Oral Word Association Test. Sensitivity analyses conducted on binary definitions of cognitive decline (>1, >1.5, or >2 standard deviations from baseline) were also associated with interleukin-6 changes.

conclusionsDelayed resolution of inflammation is associated with cognitive impairment after surgery. Monitoring interleukin-6 might provide an opportunity to intervene with anti-inflammatory therapies in vulnerable patients. CLINICAL

trial registrationNCT01980511, NCT03124303.

Indexed as

Cognitive DysfunctionInterleukin-6AgedCognitionHumansInflammationNeuropsychological TestsProspective StudiesInterleukin-6cognitive dysfunctionexecutive functioninflammationinterleukin-6neurocognitive disorderpostoperativesurgery

Identifiers

PMID37385855
PMCPMC10925892
OpenAlexW4382199680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.