ArticleNeurology(R) neuroimmunology & neuroinflammation2023
Adoptive Allogeneic T-Cell Therapy Improves the Clinical Outcome of JC Virus Granule Cell Neuronopathy: A Case Report.
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Article in Neurology(R) neuroimmunology & neuroinflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors at 1 institution in 2 countries.
Lea Grote-LeviFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).
Nora MöhnFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).
Agnes BonifaciusFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).
Sabine Tischer-ZimmermannFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).
Finja SchweitzerFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).
Nima MahmoudiFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).
Steffi SillingFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).
Clemens WarnkeFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).ORCID 0000-0002-3510-9255
Britta Maecker-KolhoffFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).
Mike P WattjesFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).
Britta Eiz-VesperFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).ORCID 0000-0001-8378-3298
Günter U HöglingerFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.).ORCID 0000-0001-7587-6187
Thomas SkripuletzFrom the Department of Neurology (L.G.-L., N. Möhn, G.U.H., T.S.); Institute of Transfusion Medicine and Transplant Engineering (A.B., S.T.-Z., B.E.-V.), Hannover Medical School; Department of Neurology (F.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Diagnostic and Interventional Neuroradiology (N. Mahmoudi, M.P.W.), Hannover Medical School; National Reference Center for Papilloma- and Polyomaviruses (S.S.), Institute of Virology, University of Cologne; Department of Pediatric Hematology and Oncology (B.M.-K.), Hannover Medical School, Germany; and German Center for Infection Research (DZIF) (B.M.-K., B.E.-V.). skripuletz.thomas@mh-hannover.de.ORCID 0000-0001-8550-335X
University of Cologne · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesJC virus granule cell neuronopathy is a potentially fatal otherwise highly disabling disease without an approved therapeutic option. This case report presents the positive record to T-cell therapy in JC virus granule cell neuronopathy.
methodsThe patient represented with subacute cerebellar symptoms. Diagnosis of JC virus granule cell neuronopathy was made because of infratentorially accentuated brain volume atrophy shown by brain MRI and the detection of JC virus DNA in the CSF.
resultsSix doses of virus-specific T cells were administered. Within 12 months after therapy initiation, the patient showed clear clinical benefit with improvement of symptoms, and JC viral DNA load significantly declined. DISCUSSION: We present the case report of a positive response to T-cell therapy in JC virus granule cell neuronopathy, leading to an improvement of symptoms.
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Hematopoietic Stem Cell TransplantationJC VirusAtrophyCell- and Tissue-Based TherapyCerebellumHumans
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