ArticleAJNR. American journal of neuroradiology2023
Perifocal Edema in Patients with Meningioma is Associated with Impaired Whole-Brain Connectivity as Detected by Resting-State fMRI.
Article in AJNR. American journal of neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The unseen impact - a deep dive into neurocognitive impairment among patients with intracranial meningiomas: a comprehensive systematic review of the literature.Neurosurgical review · 2024Pooled it
- Identification of abnormal neural language networks by reading "brainprints" in patients with brain tumors.Neuroimage. Reports · 2026Article
- Brain dysconnectivity patterns associated with chronic back pain development.Brain informatics · 2026Article
- Reducing functional dysconnectivity in people with schizophrenia spectrum disorders.BJPsych open · 2025Article
- Review
- Quantification of brain functional connectivity deviations in individuals: A scoping review of functional MRI studies.NeuroImage. Clinical · 2025Article
- Reorganization of brain networks in olfactory groove meningioma patients: a pilot resting-state fMRI study.Frontiers in neurology · 2025Article
- Denoising strategies of functional connectivity MRI data in lesional and non-lesional brain diseases.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Correlation of Molecular Status with Preoperative Olfactory Function in Olfactory Groove Meningioma.Cancers · 2024Article
- Functional connectivity MRI provides an imaging correlate for chimeric antigen receptor T-cell-associated neurotoxicity.Neuro-oncology advancesArticle
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMeningiomas are intracranial tumors that usually carry a benign prognosis. Some meningiomas cause perifocal edema. Resting-state fMRI can be used to assess whole-brain functional connectivity, which can serve as a marker for disease severity. Here, we investigated whether the presence of perifocal edema in preoperative patients with meningiomas leads to impaired functional connectivity and if these changes are associated with cognitive function. MATERIALS AND
methodsPatients with suspected meningiomas were prospectively included, and resting-state fMRI scans were obtained. Impairment of functional connectivity was quantified on a whole-brain level using our recently published resting-state fMRI-based marker, called the dysconnectivity index. Using uni- and multivariate regression models, we investigated the association of the dysconnectivity index with edema and tumor volume as well as cognitive test scores.
resultsTwenty-nine patients were included. In a multivariate regression analysis, there was a highly significant association of dysconnectivity index values and edema volume in the total sample and in a subsample of 14 patients with edema, when accounting for potential confounders like age and temporal SNR. There was no statistically significant association with tumor volume. Better neurocognitive performance was strongly associated with lower dysconnectivity index values.
conclusionsResting-state fMRI showed a significant association between impaired functional connectivity and perifocal edema, but not tumor volume, in patients with meningiomas. We demonstrated that better neurocognitive function was associated with less impairment of functional connectivity. This result shows that our resting-state fMRI marker indicates a detrimental influence of peritumoral brain edema on global functional connectivity in patients with meningiomas.
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