ArticleThe European respiratory journal2023
Antiviral CD8
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Article in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
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32 citing papers in PubMed, 31 citations in OpenAlex.
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- Single-Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein-Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Polysialic acid is associated with immune activation in human peripheral blood nuclear cells.Glycobiology · 2026Article
- Integrating multi-source data and machine learning to Decipher the psoriasis-COPD comorbidity.Clinical and experimental medicine · 2026Article
- Neutrophil extracellular traps in asthma and chronic obstructive pulmonary disease: pathogenic roles, and therapeutic opportunities.Frontiers in immunology · 2026Review
- Article
- Gut microbiota dysbiosis and the gut-lung axis in COPD: mechanisms, clinical relevance, and microbiota-targeted interventions.Frontiers in cell and developmental biology · 2026Review
- Machine learning assisted immune profiling of COPD identifies a unique emphysema subtype independent of GOLD stage.iScience · 2025Article
- An MHC-Related Gene's Signature Predicts Prognosis and Immune Microenvironment Infiltration in Glioblastoma.International journal of molecular sciences · 2025Article
- A comprehensive bioinformatics analysis of pathways and biomarkers shared between type 2 diabetes mellitus and chronic obstructive pulmonary disease.Frontiers in immunology · 2025Article
- Pathogenic Cell in COPD: Mechanisms of Airway Remodeling, Immune Dysregulation, and Therapeutic Implications.International journal of chronic obstructive pulmonary disease · 2025Review
- Immune cell regulatory networks in chronic obstructive pulmonary disease: mechanistic analysis from innate to adaptive immunity.Frontiers in immunology · 2025Review
- Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD.Frontiers in immunology · 2025Article
- Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema Via Activating NRF1/2-P62 Axis and Suppressing IRF4 Transcription.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Early career member highlights from the 22nd ERS Lung Science Conference: development of chronic lung diseases - from life-spanning mechanisms to preventive therapy.ERJ open research · 2024Article
- Review
- The Relationship between Smoking and Susceptibility to HIV Infection: A Two-Sample Mendelian Randomization Analysis.Biomedicines · 2024Article
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Authors and funding
31 authors at 10 institutions in 3 countries.
Jie ChenInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Xinyuan WangInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Adrian SchmalenDepartment of Veterinary Sciences, LMU Munich, Martinsried, Germany.ORCID 0000-0003-2462-2675
Sophia HainesInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Martin WolffInstitute of Experimental Medicine, Christian-Albrechts University Kiel, Kiel, Germany.
Huan MaInstitute of Experimental Medicine, Christian-Albrechts University Kiel, Kiel, Germany.
Huabin ZhangNeurosurgery Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Mircea Gabriel StoleriuInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Johannes NowakInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Misako NakayamaInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Marta BuenoDivision of Pulmonary and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Judith BrandsDivision of Pulmonary and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Ana L MoraDivision of Pulmonary and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Janet S LeeDivision of Pulmonary and Critical Care Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Susanne Krauss-EtschmannInstitute of Experimental Medicine, Christian-Albrechts University Kiel, Kiel, Germany.ORCID 0000-0001-5945-5702
Anna DmitrievaInstitute of Asthma and Allergy Prevention, Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.
Marion FrankenbergerInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Thomas P HoferImmunoanalytics - Working Group Tissue Control of Immunocytes, Helmholtz Center Munich, Munich, Germany.ORCID 0000-0002-9713-3138
Elfriede NoessnerImmunoanalytics - Working Group Tissue Control of Immunocytes, Helmholtz Center Munich, Munich, Germany.
Andreas MoosmannDZIF Group Host Control of Viral Latency and Reactivation, Department of Medicine III, LMU-Klinikum, Munich, Germany.
Jürgen BehrDepartment of Medicine V, University Hospital, LMU Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Munich, Germany.
Katrin MilgerDepartment of Medicine V, University Hospital, LMU Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Munich, Germany.ORCID 0000-0003-2914-8773
Cornelia A DeegDepartment of Veterinary Sciences, LMU Munich, Martinsried, Germany.
Claudia A Staab-WeijnitzInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Stefanie M HauckMetabolomics and Proteomics Core, Helmholtz Center Munich, Munich, Germany.
Heiko AdlerInstitute of Asthma and Allergy Prevention, Helmholtz Center Munich, Member of the German Center of Lung Research (DZL), Munich, Germany.
Torsten GoldmannHistology, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Borstel, Germany.ORCID 0000-0002-1621-560X
Karoline I GaedeBioMaterialBank North, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Popgen 2.0 Network, (P2N), Borstel, Germany.
Jochen BehrendsCore Facility Fluorescence Cytometry, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.ORCID 0000-0002-0648-8911
Ilona E KammerlInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
Silke MeinersInstitute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany smeiners@fz-borstel.de.
Helmholtz Zentrum München · DEGerman Center for Lung Research · DEChristian-Albrechts-Universität zu Kiel · DEResearch Center Borstel - Leibniz Lung Center · DEUniversity of Pittsburgh · USCentral South University · CNLMU Klinikum · DEMax Planck Institute of Neurobiology · DESecond Affiliated Hospital of Guangzhou Medical University · CNWashington University in St. Louis · US
Funding
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MMapping Age-Related Changes in the LungU01HL145550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, FINKEL, TOREN · 2019 to 2022
$2.4MType II Alveolar Redox Control in Fibrogenesis and ResolutionR01HL149825 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORA, ANA LUCIA, STRAUB, ADAM CARL · 2020 to 2023
$2.1MNHLBI NIH HHS 75N92020D00005NHLBI NIH HHS R01 HL149825NHLBI NIH HHS U01 HL145550NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005
Abstract
backgroundVirus infections drive COPD exacerbations and progression. Antiviral immunity centres on the activation of virus-specific CD8
methodsWe analysed the effects of cigarette smoke on cytokine- and virus-mediated induction of the immunoproteasome
resultsCigarette smoke impaired the induction of the immunoproteasome by cytokine signalling and viral infection in lung cells
conclusionOur data indicate that cigarette smoke interferes with MHC class I antigen generation and presentation and thereby contributes to impaired activation of CD8
Indexed as
Cigarette SmokingPulmonary Disease, Chronic ObstructiveAntiviral AgentsCD8-Positive T-LymphocytesCytokinesEpitopesHistocompatibility Antigens Class IHumansImmunityAntiviral AgentsCytokinesEpitopesHistocompatibility Antigens Class I
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.