ArticleEuropean heart journal2023
Joint association of loneliness and traditional risk factor control and incident cardiovascular disease in diabetes patients.
Article in European heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.
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Who cites it
81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Systematic Review of Loneliness and Social Isolation Interventions in Obesity and Obesity-Related Complications.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Efficacy of Technology-Based Interventions on the Reduction of Loneliness: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Living alone, long-term cardiometabolic stability, and medication management in adults with type 2 diabetes: a secondary analysis of the ACCORD trial.Frontiers in endocrinology · 2026Trial
- Association of Mixed Metal Exposures with Cardiovascular Disease: Insights from a Population-Based Study.Cardiovascular toxicology · 2026Article
- Associations of loneliness, social isolation and healthy lifestyle with life expectancy free of major physical disease and mental disorder.Nature communications · 2026Article
- Loneliness, Chronic Conditions, and Healthcare Engagement in Japan: A Nationwide Cross-Sectional Study.JMA journal · 2026Article
- Association between residential physical environmental exposures and multidimensional successful ageing in the UK biobank.BMC public health · 2026Article
- Loneliness, traditional risk factor control, genetic predisposition, and development of musculoskeletal disorders.Rheumatology (Oxford, England) · 2026Article
- Social isolation and loneliness associate with early menopause and mortality in women: a UK Biobank cohort study.BMC medicine · 2026Article
- Interacting and joint effects of frailty and depressive symptoms in relation to risk of cardio-oncology comorbidity in older adults from three prospective cohorts.BMC geriatrics · 2026Article
- Integration of stress hyperglycemia ratio and c-reactive protein level improves postoperative acute kidney injury risk stratification after noncardiac surgery: A nested case-control study.Pakistan journal of medical sciences · 2026Article
- Combined effects of social health and long-term exposure to fine particulate matter on cardiovascular disease in Chinese middle-aged and older adults.Social psychiatry and psychiatric epidemiology · 2026Article
- Living arrangements and cognitive resilience in aging: unraveling distinct pathways through plasma biomarkers.The journal of prevention of Alzheimer's disease · 2026Article
- Social Disconnection, Genetic Risk, and the Incidence of Degenerative Valvular Heart Disease: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- Association between frailty and chronic lung diseases in middle aged and older population.BMC public health · 2026Article
- Changes in Immune-Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort.Annals of clinical and translational neurology · 2026Article
- Social isolation and 59 common health conditions: insights from observational and genetics analyses.BMC medicine · 2026Article
- Loneliness, Binge Eating, and Type 2 Diabetes: A Novel Theoretical Model Evaluation.Journal of clinical psychology in medical settings · 2026Article
- Cholesterol-high-density lipoprotein-glucose index versus triglyceride-glucose-derived indices for predicting 10-year cardiovascular mortality in the MASHAD cohort.Scientific reports · 2026Article
- Discovery and validation of a multi-protein panel for predicting non-fatal major adverse cardiovascular events in diabetic kidney disease.Frontiers in endocrinology · 2026Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimsTo investigate the prospective associations of the loneliness and social isolation scales with cardiovascular disease (CVD) risk in diabetes patients and compare the relative importance of loneliness and social isolation with traditional risk factors. Also, the interactions of loneliness or isolation with the degree of risk factor control in relation to CVD risk were evaluated. METHODS AND
resultsA total of 18 509 participants diagnosed with diabetes from the UK Biobank were included. A two-item scale and a three-item scale were used to assess loneliness and isolation levels, respectively. The degree of risk factor control was defined as numbers of glycated hemoglobin (HbA1c), blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), smoking, and kidney condition controlled within the target range. During a mean follow-up of 10.7 years, 3247 total CVD incidents were documented, including 2771 coronary heart disease and 701 strokes. In the fully adjusted model, compared with participants with the lowest loneliness score (zero), hazard ratios (95% confidence interval) for CVD were 1.11 (1.02 and 1.20) and 1.26 (1.11 and 1.42) for participants with a loneliness scale of 1 and 2, respectively (P-trend < 0.001). No significant associations were observed for social isolation. Loneliness ranked higher in relative strength for predicting CVD than the lifestyle risk factors in diabetes patients. A significant additive interaction between loneliness and the degree of risk factor control on the risk of CVD was observed (P for additive interaction = 0.005).
conclusionAmong diabetes patients, loneliness, but not social isolation scale, is associated with a higher risk of CVD and shows an additive interaction with the degree of risk factor control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.