Evidence map›Paper›PMID 37385324›Full record

ArticleClinical immunology (Orlando, Fla.)2023

DOCK8 is essential for neutrophil mediated clearance of cutaneous S. aureus infection.

Hazel Wilkie, Maheshwor Timilshina, Siti Rahmayanti, Mrinmoy Das, Tyler Pelovitz, Raif S Geha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. DOCK8 in immune cells: roles and mechanisms.Frontiers in immunology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hazel WilkieDivision of Immunology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, Boston, MA, USA.
Maheshwor TimilshinaDivision of Immunology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, Boston, MA, USA.
Siti RahmayantiDivision of Plastic & Reconstructive Surgery, Brigham and Womens Hospital, Harvard Medical School, USA.
Mrinmoy DasDivision of Immunology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, Boston, MA, USA.
Tyler PelovitzDivision of Immunology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, Boston, MA, USA.
Raif S GehaDivision of Immunology, Boston Children's Hospital and Department of Pediatrics Harvard Medical School, Boston, MA, USA. Electronic address: raif.geha@childrens.harvard.edu.
Boston Children's Hospital · USBrigham and Women's Hospital · US

Funding

Genetic and microbial modifiers of Atopic Dermatitis (AD): Mechanisms of increased AD severity in patients with the R576 polymorphism in IL-4Ra and impact of S aureus skin decolonization on ADU01AI152033 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI RAIF SALIM GEHA, WANDA PHIPATANAKUL · 2020 to 2026
$3.7M
Molecular and cellular mechanisms in food anaphylaxisR01AI153257 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GEHA, RAIF SALIM · 2020 to 2024
$2.7M
NIAID NIH HHS R01 AI153257NIAID NIH HHS U01 AI152033
6 · The paper itself

Abstract

DOCK8 deficient patients are susceptible to skin infection with Staphylococcus aureus which is normally cleared by neutrophils. We examined the mechanism of this susceptibility in mice. Dock8

Indexed as

Methicillin-Resistant Staphylococcus aureusSkin Diseases, InfectiousStaphylococcal InfectionsAnimalsGuanine Nucleotide Exchange FactorsMiceMice, Inbred C57BLNeutrophilsSkinStaphylococcus aureusDock8 protein, mouseGuanine Nucleotide Exchange FactorsDOCK8 deficiencyNeutrophilsPhagocytosisS. aureus

Identifiers

PMID37385324
PMCPMC10529992
OpenAlexW4382199747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.