ArticleCurrent biology : CB2023
Sleep-like changes in neural processing emerge during sleep deprivation in early auditory cortex.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- "Schrödinger's Rat": Testing Consciousness Under Anesthesia Alters Brain State and Neuronal Responses in Auditory Cortex.Nature and science of sleep · 2026Article
- An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening.Science advances · 2025Article
- Abrupt and Gradual Changes in Neuronal Processing upon Falling Asleep and Awakening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sleep-like cortical dynamics during wakefulness and their network effects following brain injury.Nature communications · 2024Review
- Article
- Reduced neural feedback signaling despite robust neuron and gamma auditory responses during human sleep.Nature neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Insufficient sleep is commonplace in modern lifestyle and can lead to grave outcomes, yet the changes in neuronal activity accumulating over hours of extended wakefulness remain poorly understood. Specifically, which aspects of cortical processing are affected by sleep deprivation (SD), and whether they also affect early sensory regions, remain unclear. Here, we recorded spiking activity in the rat auditory cortex along with polysomnography while presenting sounds during SD followed by recovery sleep. We found that frequency tuning, onset responses, and spontaneous firing rates were largely unaffected by SD. By contrast, SD decreased entrainment to rapid (≥20 Hz) click trains, increased population synchrony, and increased the prevalence of sleep-like stimulus-induced silent periods, even when ongoing activity was similar. Recovery NREM sleep was associated with similar effects as SD with even greater magnitude, while auditory processing during REM sleep was similar to vigilant wakefulness. Our results show that processes akin to those in NREM sleep invade the activity of cortical circuits during SD, even in the early sensory cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.