Evidence map›Paper›PMID 37385232›Full record

ArticleEuropean addiction research2023

Cause-Specific Mortality among Patients in Treatment for Opioid Use Disorder in Multiple Settings: A Prospective Comparative Cohort Study.

Desiree Eide, Svetlana Skurtveit, Thomas Clausen, Morten Hesse, Viktor Mravčík, Blanka Nechanská, Gabriela Rolova, Birgitte Thylstrup, Christian Tjagvad, Abdu Kedir Seid and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European addiction research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Health-related quality of life measures as predictors for recurrent hospitalization and mortality among patients in heroin-assisted treatment.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Desiree EideNorwegian Centre for Addiction Research, University of Oslo, Oslo, Norway.
Svetlana SkurtveitNorwegian Centre for Addiction Research, University of Oslo, Oslo, Norway.
Thomas ClausenNorwegian Centre for Addiction Research, University of Oslo, Oslo, Norway.
Morten HesseCentre for Alcohol and Drug Research, Aarhus University, Aarhus, Denmark.
Viktor MravčíkDepartment of Addictology, First Faculty of Medicine, Charles University, Prague, Czechia.
Blanka NechanskáDepartment of Addictology, First Faculty of Medicine, Charles University, Prague, Czechia.
Gabriela RolovaDepartment of Addictology, First Faculty of Medicine, Charles University, Prague, Czechia.
Birgitte ThylstrupCentre for Alcohol and Drug Research, Aarhus University, Aarhus, Denmark.
Christian TjagvadNorwegian Centre for Addiction Research, University of Oslo, Oslo, Norway.
Abdu Kedir SeidCentre for Alcohol and Drug Research, Aarhus University, Aarhus, Denmark.
Ingvild OdsbuNorwegian Institute of Public Health, Oslo, Norway.
Roman GabrhelíkDepartment of Addictology, First Faculty of Medicine, Charles University, Prague, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAmong people receiving current or previous opioid maintenance treatment (OMT), the leading cause of premature death is an opioid overdose. However, other causes of mortality remain high in this group. An understanding of causes of deaths across multiple settings can be useful in informing more comprehensive prevention responses. The aim of this study was to describe all non-overdose causes of death in three national cohorts (Czechia, Denmark, and Norway) among OMT patients and to explore associations of non-overdose mortality with age and gender.

methodsThis prospective comparative cohort study used national mortality registry databases for OMT patients from Czechia (2000-2019), Denmark (2000-2018), and Norway (2010-2019). Crude mortality rates and age-standardized mortality rates (ASMRs) were calculated as deaths per 1,000 person years for cause-specific mortality.

resultsIn total, 29,486 patients were included, with 5,322 deaths recorded (18%). We found variations in causes of death among the cohorts and within gender and age groups. The leading non-overdose causes of death were accidents in Czechia and Denmark, and neoplasms in Norway. Cardiovascular deaths were highest in Czechia, particularly for women in OMT (ASMR 3.59 vs. 1.24 in Norway and 1.87 in Denmark).

conclusionThis study found high rates of preventable death among both genders and all age groups. Different demographic structures, variations in risk exposure, as well as variations in coding practices can explain the differences. The findings support increased efforts towards screening and preventative health initiatives among OMT patients specific to the demographic characteristics in different settings.

Indexed as

AccidentsCardiovascular DiseasesCause of DeathNeoplasmsOpioid-Related DisordersAdultCohort StudiesCzech RepublicDenmarkDrug OverdoseFemaleHumansMaleMiddle AgedNorwayOpiate Substitution TreatmentMortalityOpioid maintenance treatmentOverdoseRegistrySubstance abuse

Identifiers

PMID37385232
PMCPMC10614278

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.