Evidence map›Paper›PMID 37385168›Full record

ArticleThe American journal of cardiology2023

Geographical Patterns and Risk Factor Association of Cardio-Oncology Mortality in the United States.

Issam Motairek, Weichuan Dong, Pedro Rvo Salerno, Scott E Janus, Sarju Ganatra, Zhuo Chen, Avirup Guha, Mohamed He Makhlouf, Neda Shafiabadi Hassani, Sanjay Rajagopalan and 1 more

Abstract read
In one paragraph

Article in The American journal of cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Issam MotairekHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Weichuan DongDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Pedro Rvo SalernoHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Scott E JanusHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Sarju GanatraCardio-Oncology Program, Lahey Clinic, Burlington, Massachusetts.
Zhuo ChenHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Avirup GuhaCardio-Oncology Program, Georgia Cancer Center, Medical College of Georgia at Augusta University, Augusta, Georgia.
Mohamed He MakhloufHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Neda Shafiabadi HassaniHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Sanjay RajagopalanHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Sadeer G Al-KindiHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address: Sadeer.Al-Kindi@uhhospitals.org.

Funding

ACHIEVE P3 - CHDP50MD017351 · NIMHD · WAYNE STATE UNIVERSITY · PI DAILEY, RHONDA K · 2021 to 2025
$21.1M
NIMHD NIH HHS P50 MD017351
6 · The paper itself

Abstract

Cardio-oncology mortality (COM) is a complex issue that is compounded by multiple factors that transcend a depth of socioeconomic, demographic, and environmental exposures. Although metrics and indexes of vulnerability have been associated with COM, advanced methods are required to account for the intricate intertwining of associations. This cross-sectional study utilized a novel approach that combined machine learning and epidemiology to identify high-risk sociodemographic and environmental factors linked to COM in United States counties. The study consisted of 987,009 decedents from 2,717 counties, and the Classification and Regression Trees model identified 9 county socio-environmental clusters that were closely associated with COM, with a 64.1% relative increase across the spectrum. The most important variables that emerged from this study were teen birth, pre-1960 housing (lead paint indicator), area deprivation index, median household income, number of hospitals, and exposure to particulate matter air pollution. In conclusion, this study provides novel insights into the socio-environmental drivers of COM and highlights the importance of utilizing machine learning approaches to identify high-risk populations and inform targeted interventions for reducing disparities in COM.

Indexed as

Air PollutionNeoplasmsAdolescentCross-Sectional StudiesEnvironmental ExposureHumansRisk FactorsUnited States

Identifiers

PMID37385168
PMCPMC10529631

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.