Evidence map›Paper›PMID 37384815›Full record

ArticleACS nano2023

Ultrasensitive and Specific Clustered Regularly Interspaced Short Palindromic Repeats Empowered a Plasmonic Fiber Tip System for Amplification-Free Monkeypox Virus Detection and Genotyping.

Yuzhi Chen, Zhi Chen, Tianzhong Li, Meng Qiu, Jinghan Zhang, Yan Wang, Wu Yuan, Aaron Ho-Pui Ho, Omar Al-Hartomy, Swelm Wageh and 6 more

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
33.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 84 citations in OpenAlex.

  1. Review
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  8. Review
  9. Mpox disease, diagnosis, and point of care platforms.Bioengineering & translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Yuzhi ChenCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China.ORCID 0000-0002-5975-3053
Zhi ChenCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China.ORCID 0000-0002-7624-3143
Tianzhong LiCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China.
Meng QiuCollege of Chemistry and Chemical Engineering, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, Shandong 266100, People's Republic of China.ORCID 0000-0002-3312-4873
Jinghan ZhangCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China.
Yan WangCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China.
Wu YuanDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong 999077, People's Republic of China.ORCID 0000-0001-9405-519X
Aaron Ho-Pui HoDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong 999077, People's Republic of China.ORCID 0000-0001-5001-5911
Omar Al-HartomyDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Swelm WagehDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-9494-4568
Abdullah G Al-SehemiResearch Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.ORCID 0000-0002-6793-3038
Xin ShiChina Medical University, Shenyang, Liaoning 110001, People's Republic of China.
Jingfeng LiCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China.
Zhongjian XieInstitute of Pediatrics, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, People's Republic of China.
Li XuejinCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China.
Han ZhangCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China.ORCID 0000-0002-0166-1973
Shenzhen University · CNChinese University of Hong Kong · HKKing Abdulaziz University · SAKing Khalid University · SAManchester Metropolitan University · GBOcean University of China · CNShenzhen Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The urgent necessity for highly sensitive diagnostic tools has been accentuated by the ongoing mpox (monkeypox) virus pandemic due to the complexity in identifying asymptomatic and presymptomatic carriers. Traditional polymerase chain reaction-based tests, despite their effectiveness, are hampered by limited specificity, expensive and bulky equipment, labor-intensive operations, and time-consuming procedures. In this study, we present a clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a-based diagnostic platform with a surface plasmon resonance-based fiber tip (CRISPR-SPR-FT) biosensor. The compact CRISPR-SPR-FT biosensor, with a 125 μm diameter, offers high stability and portability, enabling exceptional specificity for mpox diagnosis and precise identification of samples with a fatal mutation site (L108F) in the

Indexed as

Biosensing TechniquesMpox, MonkeypoxGenotypeHumansMonkeypox virusMutationPandemicsAmplification-freeBiosensorClustered regularly interspaced short palindromic repeats (CRISPR)Monkeypox virusSurface plasmon resonance-based fiber tip

Identifiers

PMID37384815
PMCPMC10340103
OpenAlexW4382516976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.