Evidence map›Paper›PMID 37384794›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

A Multicenter Retrospective Cohort Study to Characterize Patients Hospitalized With Multisystem Inflammatory Syndrome in Adults and Coronavirus Disease 2019 in the United States, 2020-2021.

Michael Melgar, Joseph Y Abrams, Shana Godfred-Cato, Ami B Shah, Amit Garg, Andrew Strunk, Mangala Narasimhan, Jonathan Koptyev, Alexandra Norden, David Musheyev and 25 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 8 institutions in 1 country.

Michael MelgarCOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0003-3243-9854
Joseph Y AbramsCOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Shana Godfred-CatoCOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Ami B ShahCOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Amit GargDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.ORCID 0000-0003-0886-6856
Andrew StrunkDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Mangala NarasimhanDivision of Pulmonary, Critical Care, and Sleep Medicine, Northwell Health LIJ/NSUH Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Jonathan KoptyevDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Alexandra NordenDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
David MusheyevDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Fahmida RashidDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Rachel TannenbaumDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Rosa M Estrada-Y-MartinDivisions of Critical Care, Pulmonary, and Sleep Medicine, McGovern Medical School at UTHealth, The University of Texas at Houston, Houston, Texas, USA.
Bela PatelDivisions of Critical Care, Pulmonary, and Sleep Medicine, McGovern Medical School at UTHealth, The University of Texas at Houston, Houston, Texas, USA.
Siddharth KaranthDivisions of Critical Care, Pulmonary, and Sleep Medicine, McGovern Medical School at UTHealth, The University of Texas at Houston, Houston, Texas, USA.
Chad J AchenbachDivision of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Gavin T HallDivision of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Sara M HockneyDivision of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-7082-7482
Matthew CaputoHavey Institute for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Lilian M AbboDepartment of Infection Prevention and Control, Jackson Health System, Miami, Florida, USA.
Laura BeauchampsDivision of Infectious Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Stephen MorrisDivision of Infectious Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Renzo O CifuentesDivision of Infectious Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Annabelle de St MauriceDivision of Infectious Diseases, Department of Pediatrics, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, California, USA.ORCID 0000-0001-7368-7403
Douglas S BellDivision of General Internal Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
Kavitha K PrabakerDepartment of Clinical Epidemiology and Infection Prevention, University of California, Los Angeles, Los Angeles, California, USA.
Fernando J Sanz VidorretaClinical and Translational Science Institute, University of California, Los Angeles, Los Angeles, California, USA.
Evan BryantDepartment of Clinical Epidemiology and Infection Prevention, University of California, Los Angeles, Los Angeles, California, USA.
David K CohenDepartment of Clinical Epidemiology and Infection Prevention, University of California, Los Angeles, Los Angeles, California, USA.
Rohith MohanDepartment of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Christopher P LibbyDepartment of Emergency Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Spencer SooHooDivision of Informatics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Tristel J DomingoDivision of Informatics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Angela P CampbellCOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Ermias D BelayCOVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell · USCenters for Disease Control and Prevention · USUniversity of California, Los Angeles · USCedars-Sinai Medical Center · USNorthwestern University · USUniversity of Miami · USThe University of Texas Health Science Center at Houston · USNorthwell Health · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
CDC HHS 75D30121C10590NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001881NIH HHS UL1TR001422
6 · The paper itself

Abstract

backgroundThe diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated multisystem inflammatory syndrome in adults (MIS-A) requires distinguishing it from acute coronavirus disease 2019 (COVID-19) and may affect clinical management.

methodsIn this retrospective cohort study, we applied the US Centers for Disease Control and Prevention case definition to identify adults hospitalized with MIS-A at 6 academic medical centers from 1 March 2020 to 31 December 2021. Patients MIS-A were matched by age group, sex, site, and admission date at a 1:2 ratio to patients hospitalized with acute symptomatic COVID-19. Conditional logistic regression was used to compare demographic characteristics, presenting symptoms, laboratory and imaging results, treatments administered, and outcomes between cohorts.

resultsThrough medical record review of 10 223 patients hospitalized with SARS-CoV-2-associated illness, we identified 53 MIS-A cases. Compared with 106 matched patients with COVID-19, those with MIS-A were more likely to be non-Hispanic black and less likely to be non-Hispanic white. They more likely had laboratory-confirmed COVID-19 ≥14 days before hospitalization, more likely had positive in-hospital SARS-CoV-2 serologic testing, and more often presented with gastrointestinal symptoms and chest pain. They were less likely to have underlying medical conditions and to present with cough and dyspnea. On admission, patients with MIS-A had higher neutrophil-to-lymphocyte ratio and higher levels of C-reactive protein, ferritin, procalcitonin, and D-dimer than patients with COVID-19. They also had longer hospitalization and more likely required intensive care admission, invasive mechanical ventilation, and vasopressors. The mortality rate was 6% in both cohorts.

conclusionsCompared with patients with acute symptomatic COVID-19, adults with MIS-A more often manifest certain symptoms and laboratory findings early during hospitalization. These features may facilitate diagnosis and management.

Indexed as

Connective Tissue DiseasesCOVID-19AdultHumansRetrospective StudiesSARS-CoV-2Systemic Inflammatory Response SyndromeUnited StatesCOVID-19MIS-Amultisystem inflammatory syndrome in adultsSARS-CoV-2

Identifiers

PMID37384794
PMCPMC10654854
OpenAlexW4382516965

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Registered trials

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