ArticleScience (New York, N.Y.)2023
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
16.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Coping with copper: a bibliometric analysis of copper's role in cancer pathogenesis and treatment.Systematic reviews · 2025Pooled it
- Mechanisms, regulation and clinical relevance of necroptosis.Nature reviews. Molecular cell biology · 2026Review
- AMPK as a central regulator of necroptosis: mechanistic insights and therapeutic implications.Journal of physiology and biochemistry · 2026Review
- Interaction between p-AMPK and RIPK3 reveals a mechanism by which AdipoAI suppresses necroptosis to attenuate periodontitis.Journal of translational medicine · 2026Article
- PANoptosis in the pathogenesis of myelodysplastic syndromes.Molecular oncology · 2026Review
- Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Interplay between ischemia-reperfusion and metabolic reprogramming.Apoptosis : an international journal on programmed cell death · 2026Review
- Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.Cell death and differentiation · 2026Article
- Necroptosis in alveolar epithelium orchestrates lung ischemia-reperfusion injury: a multi-omics study.Respiratory research · 2026Article
- Association of the C-reactive protein-triglyceride-glucose (CTI) index and its central obesity-modified derivatives with incident cardiometabolic multimorbidity: results from two prospective cohorts in China and England.Cardiovascular diabetology · 2026Article
- Interacting proteins of AMPK studied using TurboID proximity labeling technology.Experimental and therapeutic medicine · 2026Article
- RIPK 1 in Alzheimer's Disease: Research Progress Integrating Pathogenesis on Necroptosis-Related Neuroinflammation, and Potential Therapeutic Strategies.Biomedicines · 2026Review
- Stiripentol induces ER stress and pyroptosis in pancreatic cancer cells under metabolic stress by dysregulating SFAs/UFAs homeostasis.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- PPP1R3G-RIPK1-ZBP1 axis activates early-stage apoptosis and late-stage necroptosis to promote doxorubicin-induced cardiotoxicity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy.Nature communications · 2026Article
- Shaping death: how the microbiome regulates tumour cell demise and therapy response.Cancer metastasis reviews · 2026Review
- Joint assessment of insulin resistance surrogate indices and basal metabolic rate for primary prevention of cardiometabolic multimorbidity: evidence from the China Health and Retirement Longitudinal Study (2011-2020).Cardiovascular diabetology · 2026Article
- Hepatic Hypoxia-Inducible Factor 1α Mediates Ferroptosis via Transferrin Receptor 1 in Acute Liver Injury.Antioxidants (Basel, Switzerland) · 2026Article
- Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1.The Journal of experimental medicine · 2026Article
- Integrated Transcriptomics and Experimental Validation Reveal Müller Cell-Driven PANoptosis in Diabetic Retinopathy via PSAP-GPR37 Signaling.International journal of general medicine · 2026Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 8 institutions in 4 countries.
Tao Zhang *Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0009-0004-1704-1455
Daichao Xu *Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.ORCID 0000-0002-3286-4968
Elijah Trefts *The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-0599-1486
Mingming Lv *Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0003-4401-7464
Hiroyuki InuzukaDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-4892-0047
Guobin SongDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Min LiuTransfusion Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Jianlin LuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jianping LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.ORCID 0000-0001-7090-2112
Chen ChuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0001-8084-0867
Min WangDepartment of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China.
Huibing WangDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6980-577X
Huyan MengF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-1511-6156
Hui LiuDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Yuan ZhuangDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0009-0005-4955-7146
Xingxing XieInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.
Fabin DangDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-1954-8231
Dongxian GuanDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Yuqin MenDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Shuwen JiangDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cong JiangDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Xiaoming DaiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-9671-8137
Jing LiuDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-3113-4015
Zhen WangDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0009-0008-5083-1853
Peiqiang YanDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Jingchao WangDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Zhenbo TuDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-3720-7844
Mrigya BabutaDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Emily EricksonDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0003-3494-2605
Alissandra L HillisDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-6667-1291
Christian C DibbleDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-1122-9017
John M AsaraDivision of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-7450-2589
Gyongy SzaboDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0003-0836-2527
Piotr SicinskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-8859-5234
Ji MiaoDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0869-4492
Yu-Ru LeeInstitute of Biomedical Sciences, Academia Sinica, Taipei 115201, Taiwan.ORCID 0000-0001-6592-6806
Lifeng PanState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 200032 Shanghai, China.ORCID 0000-0002-9229-6288
Reuben J ShawThe Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-1555-8977
Junying YuanInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.ORCID 0000-0003-2405-6036
Wenyi WeiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0003-0512-3811
Beth Israel Deaconess Medical Center · USBoston Children's Hospital · USHarvard University · USSalk Institute for Biological Studies · USShanghai Institute of Organic Chemistry · CNInstitute of Biomedical Sciences, Academia Sinica · TWSt. Jude Children's Research Hospital · USTongji Hospital · CN
Funding
Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MAlcohol and Monocyte Signaling Administrative SupplementR01AA011576 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Gyongyi Szabo · 1998 to 2026
$9.3MTissue and Pathology CoreP01CA250959 · NCI · DANA-FARBER CANCER INST · PI BROWN, MYLES A · 2020 to 2024
$8.6MDeciphering the physiological role and interplay between ubiquitination and phosphorylation pathways to guide targeted cancer therapiesR35CA253027 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Wenyi Wei · 2020 to 2026
$6.2MTLR4 Signaling in alcoholic liver diseaseR01AA017729 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SZABO, GYONGYI · 2009 to 2021
$4.3MNovel regulation of PI3K/Akt to direct targeted breast cancer therapiesR01CA177910 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEI, WENYI · 2013 to 2023
$3.9MNovel therapeutic approaches with CDK4/6 inhibitors for melanoma treatmentR01CA236226 · NCI · DANA-FARBER CANCER INST · PI SICINSKI, PETER · 2019 to 2023
$2.4MRole of TAZ in metabolic regulation in both normal and insulin resistant statesR01DK124328 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI MIAO, JI · 2021 to 2025
$2.2MThe Function of CDK5 in MetastasisR01CA239660 · NCI · DANA-FARBER CANCER INST · PI SICINSKI, PETER · 2019 to 2023
$2.2MNovel functions of D-type and E-type cyclins in normal and in cancer cellsR01CA202634 · NCI · DANA-FARBER CANCER INST · PI SICINSKI, PETER · 2016 to 2020
$2.1MCopper and copper-binding proteins in insulin resistance-associated metabolic diseaseR01DK133331 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI MIAO, JI · 2022 to 2025
$1.9MRole of Vitamin B5 and Coenzyme A Metabolism in PI3K Driven TumorigenesisR00CA194314 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DIBBLE, CHRISTIAN · 2018 to 2020
$747kNCI NIH HHS P01 CA120964NCI NIH HHS P01 CA250959NCI NIH HHS R00 CA194314NCI NIH HHS R01 CA177910NCI NIH HHS R01 CA202634NCI NIH HHS R01 CA236226NCI NIH HHS R01 CA239660NCI NIH HHS R35 CA253027NIAAA NIH HHS R01 AA011576NIAAA NIH HHS R01 AA017729NIDDK NIH HHS R01 DK124328NIDDK NIH HHS R01 DK133331
Abstract
Adenosine monophosphate-activated protein kinase (AMPK) activity is stimulated to promote metabolic adaptation upon energy stress. However, sustained metabolic stress may cause cell death. The mechanisms by which AMPK dictates cell death are not fully understood. We report that metabolic stress promoted receptor-interacting protein kinase 1 (RIPK1) activation mediated by TRAIL receptors, whereas AMPK inhibited RIPK1 by phosphorylation at Ser
Indexed as
AMP-Activated Protein KinasesEnergy MetabolismNecroptosisReceptor-Interacting Protein Serine-Threonine KinasesStress, PhysiologicalAnimalsInflammationIschemiaMicePhosphorylationAMP-Activated Protein KinasesPrkaa1 protein, mouseReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.