Evidence map›Paper›PMID 37384669›Full record

ArticleScience (New York, N.Y.)2023

Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.

Hao Wu, Elise N Muñoz, Laura J Hsieh, Un Seng Chio, Muryam A Gourdet, Geeta J Narlikar, Yifan Cheng

Open access · hybridAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cryo-EM structure of ALC1 in an open conformation bound to a PARylated nucleosome.Acta crystallographica. Section D, Structural biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Mechanistic insights into INO80-type chromatin remodelers.Current opinion in structural biology · 2025
    Review
  16. Review
  17. Article
  18. Beyond the mono-nucleosome.Biochemical Society transactions · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hao Wu *Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-1070-0292
Elise N Muñoz *Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0003-4341-8119
Laura J HsiehDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-7615-6226
Un Seng ChioDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-5295-2690
Muryam A GourdetDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-8007-092X
Geeta J NarlikarDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-1920-0147
Yifan ChengDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-9535-0369
University of California, San Francisco · USHoward Hughes Medical Institute · US

Funding

Measuring the lifetime and mechanical stability of phase-separated heterochromatin domainsR35GM127020 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GEETA J NARLIKAR · 2018 to 2026
$7.3M
Advancing cryo-EM technology to address difficult biological questionsR35GM140847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yifan Cheng · 2021 to 2026
$2.1M
Acquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0M
Glacios™ Cryo Transmission Electron Microscope with 200 kV XFEG opticsS10OD026881 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2019 to 2019
$1.8M
Linux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456k
GPU Computing Enabled Linux Computer ClusterS10RR026814 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2010 to 2010
$228k
Molecular mechanisms of the ACF chromatin remodeling complexF32GM137463 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIO, UN SENG · 2020 to 2022
$201k
Dissecting the unique chaperone mechanism of the Rvb1/Rvb2 AAA+ ATPase complexF31GM142271 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MUÑOZ, ELISE NOELLE · 2021 to 2023
$127k
Supplement Characterizing the mechanism of the INO80 family chromatin remodeling machineF31GM136187 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOURDET, MURYAM A.A. · 2020 to 2022
$102k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR026814NIGMS NIH HHS F31 GM136187NIGMS NIH HHS F31 GM142271NIGMS NIH HHS F32 GM137463NIGMS NIH HHS R35 GM127020NIGMS NIH HHS R35 GM140847NIH HHS S10 OD020054NIH HHS S10 OD021741NIH HHS S10 OD026881
6 · The paper itself

Abstract

Unlike other chromatin remodelers, INO80 preferentially mobilizes hexasomes, which can form during transcription. Why INO80 prefers hexasomes over nucleosomes remains unclear. Here, we report structures of

Indexed as

Chromatin Assembly and DisassemblyNucleosomesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsChromatinHistonesChromatinHistonesINO80 complex, S cerevisiaeNucleosomesSaccharomyces cerevisiae Proteins

Identifiers

PMID37384669
PMCPMC10480058
OpenAlexW4382520324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.