Evidence map›Paper›PMID 37384606›Full record

ReviewPLoS neglected tropical diseases2023

A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain.

Stephen Muhi, Joshua Osowicki, Daniel O'Brien, Paul D R Johnson, Sacha Pidot, Marcel Doerflinger, Julia L Marshall, Marc Pellegrini, James McCarthy, Timothy P Stinear

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in PLoS neglected tropical diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stephen MuhiPeter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-3161-8199
Joshua OsowickiTropical Diseases Research Group, Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Daniel O'BrienPeter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Paul D R JohnsonPeter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Sacha PidotPeter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Marcel DoerflingerWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Julia L MarshallPeter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Marc PellegriniWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
James McCarthyPeter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
Timothy P StinearPeter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.

Indexed as

Buruli UlcerMycobacterium ulceransHost-Pathogen InteractionsHumansKnowledgeNeglected Diseases

Identifiers

PMID37384606
PMCPMC10309606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.