Evidence map›Paper›PMID 37384210›Full record

ArticleCase reports in oncology

The Role of Abdominal Surgery in Refractory Immune Checkpoint Inhibitor Enterocolitis: A Case Report.

Manon Verhé, Thomas De Somer, Barbara Defoort, Erik Vanderstraeten, Els Monsaert, Vincent Bouderez, Stefanie Dias, Danielle Delombaerde, Christof Vulsteke, Christophe Van Steenkiste

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Manon VerhéDepartment of Gastroenterology, AZ Maria Middelares, Ghent, Belgium.
Thomas De SomerDepartment of Gastroenterology, AZ Maria Middelares, Ghent, Belgium.
Barbara DefoortDepartment of Surgery, AZ Maria Middelares, Ghent, Belgium.
Erik VanderstraetenDepartment of Gastroenterology, AZ Maria Middelares, Ghent, Belgium.
Els MonsaertDepartment of Gastroenterology, AZ Maria Middelares, Ghent, Belgium.
Vincent BouderezDepartment of Gastroenterology, AZ Maria Middelares, Ghent, Belgium.
Stefanie DiasIntegrated Cancer Center Ghent, Department of Medical Oncology, AZ Maria Middelares, Ghent, Belgium.
Danielle DelombaerdeIntegrated Cancer Center Ghent, Department of Medical Oncology, AZ Maria Middelares, Ghent, Belgium.
Christof VulstekeIntegrated Cancer Center Ghent, Department of Medical Oncology, AZ Maria Middelares, Ghent, Belgium.
Christophe Van SteenkisteDepartment of Gastroenterology, AZ Maria Middelares, Ghent, Belgium.
AZ Maria Middelares · BEUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article describes the case of a 73-year-old patient with grade 3 immune checkpoint inhibitor (ICI)-induced enteritis. Five different immunosuppressive agents (glucocorticoids, high-dose infliximab, methotrexate, mycophenolate mofetil, and vedolizumab) were administered, however, with no clinical or radiographical benefit. A laparotomy was performed, as the patient showed signs of intestinal obstruction, with a segmental resection of the ileal loop. Biopsy results showed multiple fibrotic strictures. The current treatment guidelines for ICI enterocolitis only include drugs as a treatment option. Nevertheless, it remains important to consider early surgical intervention in order to avoid serious complications due to persistent and pronounced inflammation. The current case highlights the importance of surgery as a treatment modality in the multidisciplinary approach for ICI-induced enteritis, which should be taken into consideration after second- or third-line treatment.

Indexed as

Abdominal surgeryCase reportImmune checkpoint inhibitor enterocolitisImmunotherapyToxicity

Identifiers

PMID37384210
PMCPMC10294263
OpenAlexW4381162416

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.