ReviewThe Lancet regional health. Southeast Asia2023
The landscape of infantile epileptic spasms syndrome in South Asia: peculiarities, challenges, and way forward.
Review in The Lancet regional health. Southeast Asia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Prevalence and incidence of infantile epileptic spasms syndrome in India: A systematic review and meta-analysis.Epilepsia open · 2026Pooled it
- Artificial intelligence-assisted detection of epileptic spasms using electroencephalographic-video analysis.Epilepsia · 2026Article
- Infantile Spasms (West Syndrome): Integrating Genetic, Neurotrophic, and Hormonal Mechanisms Toward Precision Therapy.Medicina (Kaunas, Lithuania) · 2025Review
- Delandistrogene Moxeparvovec gene therapy for Duchenne muscular dystrophy: the way forward in South Asian countries.The Lancet regional health. Southeast Asia · 2025Article
- A model-based cost-effectiveness estimates of hormonal therapy in Indian children with infantile epileptic spasms syndrome.Epilepsia open · 2025Observational
- Infantile Epileptic Spasms Syndrome Due to Neonatal Hypoglycemic Brain Injury: A Retrospective Audit.Indian pediatrics · 2025Article
- Factors Influencing the Response of Patients with Infantile Epileptic Spasms Syndrome to ACTH as Repeated First-Line Therapy.Neurology and therapy · 2025Article
- Electroclinical Landscape of Infantile Epileptic Spasms Syndrome.Indian journal of pediatrics · 2025Article
- Predictive model for initial response to first-line treatment in children with infantile epileptic spasms syndrome.Italian journal of pediatrics · 2025Article
- Short-Term Effectiveness and Tolerability of Vigabatrin Therapy in Infantile Epileptic Spasms Syndrome.Indian journal of pediatrics · 2025Article
- Update on Cannabidiol in Drug-Resistant Epilepsy.Indian journal of pediatrics · 2025Review
- Infantile-Onset Epilepsies: Steering Towards New Horizons.Indian journal of pediatrics · 2025Article
- First-choice hormonal therapies for children with infantile epileptic spasms syndrome in South Asia: A network meta-analysis of randomized controlled trials.Epilepsia open · 2024Review
- Optimal lead time for treatment of infantile epileptic spasms syndrome-a secondary data analysis.Translational pediatrics · 2024Article
- Analysis of treatment outcome variations in infantile epileptic spasms syndrome.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infantile Epileptic Spasms Syndrome (IESS), commonly known as West syndrome, is the most common cause of infantile-onset epileptic encephalopathy. There is a peculiar epidemiological profile of IESS in South Asia. Specific features identified were a preponderance of acquired structural aetiology, male gender dominance, a long treatment lag, limited availability of adrenocorticotropic hormone (ACTH) and vigabatrin, and use of carboxymethyl cellulose derivative of ACTH. Because of the significant disease burden and limited resources, there are distinctive challenges to the optimal care of children with IESS in the South Asian region. Also, there are unique opportunities to bridge these challenges and improve outcomes. This review provides an overview of the landscape of IESS in South Asia and highlights its peculiarities, various challenges, and way forward.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.