Evidence map›Paper›PMID 37383424›Full record

ArticleInternational journal of organ transplantation medicine2022

Stereological Evaluation of Rabbit Fetus Liver after Xenotransplantation of Human Wharton's Jelly-Derived Mesenchymal Stromal Cells.

Z Khodabandeh, L Rezaeian, M A Edalatmanesh, A Mogheiseh, N Tanideh, M Dianatpour, Sh Zare, H Bordbar, N Baghban, A Tamadon

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of organ transplantation medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Z KhodabandehStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
L RezaeianDepartment of Biology, Faculty of Sciences, Farhangian University, Tehran, Iran.
M A EdalatmaneshDepartment of Biology, Faculty of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
A MogheisehDepartment of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
N TanidehStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M DianatpourStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sh ZareStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
H BordbarHistomorphometry and Stereology Research Center, Shiraz University of Medical Science, Shiraz, Iran.
N BaghbanDepartment of Anatomy, Shiraz University of Medical Sciences, Shiraz, Iran.
A TamadonPerciaVista R&D Co. Shiraz, Iran.
Shiraz University of Medical Sciences · IRFarhangian University · IRIslamic Azad University of Shiraz · IRShiraz University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In-utero xenotransplantation of stem cells in abnormal fetuses effectively treats several genetic illnesses. Objective: The current research aimed to evaluate structural and morphological alterations in the liver of rabbit fetuses following xenotransplantation of human Wharton's jelly-derived mesenchymal stromal cells (hWJ-MSCs), using a stereological technique. Methods: All hWJ-MSCs were isolated from the human umbilical cord, and their authenticity was established by flowcytometry and differentiation. At gestational day 14, the rabbits were anesthetized, and hWJ-MSCs were injected into the uteri of 24 fetuses. Twenty-two fetuses were born successfully. Ten rabbit liver specimens were prepared from injected fetuses including; eight rabbits on day three following birth and two rabbits on the 21st post-natal day. The non-injected fetuses were considered positive controls. The livers of the control and hWJ-MSCs-treated rabbits were fixed, processed, stained, and examined through stereological approaches. Results: In the hWJ-MSCs-treated group, the mean liver weight and volume increased by 42% and 78% compared to the control group. The total volume of the hepatocytes increased by 63%, and that of sinusoids by three folds in the treated rabbits. The total volume of the central veins increased by 70%. The total number corresponding to hepatocytes in the experimental group increased by 112% compared to the rabbits in the control. The total volume of the hepatocyte nuclei in the experimental group increased by 117% compared to the rabbits in the control. Conclusion: After xenotransplantation of human MSCs, host tissue microenvironments (here, the rabbit liver) were altered and these included quantitative factors corresponding to the liver tissue and hepatocyte morphometric indices.

Indexed as

LiverMesenchymal stromal/stem cellsStereologyWharton’s jellyXenotransplantation

Identifiers

PMID37383424
PMCPMC10294033
OpenAlexW4382502775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.