Evidence map›Paper›PMID 37383338›Full record

ArticleMedicine in novel technology and devices2021

Microstructural abnormalities are evident by histology but not HR-pQCT at the periosteal cortex of the human tibia under CVD and T2D conditions.

Barbara Garita, Jenna Maligro, Saghi Sadoughi, Po Hung Wu, Ellen Liebenberg, Andrew Horvai, Thomas M Link, Galateia J Kazakia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine in novel technology and devices, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Patella fractures are associated with bone fragility - a retrospective study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Barbara GaritaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.
Jenna MaligroDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.
Saghi SadoughiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.
Po Hung WuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.
Ellen LiebenbergDepartment of Orthopaedic Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.
Andrew HorvaiDepartment of Pathology, University of California, San Francisco, 1825 4th St, San Francisco, CA, 94143, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.
Galateia J KazakiaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St Suite 350, San Francisco, CA, 94107, USA.

Funding

Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1M
Progression and etiology of cortical porosity in diabetic bone diseaseR01AR069670 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J · 2017 to 2023
$2.9M
In vivo imaging of cortical porosity in the peripheral skeletonK01AR056734 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J · 2009 to 2013
$594k
Visualizing Cortical Pore Space ConstituentsR03AR064004 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J · 2013 to 2015
$186k
NIAMS NIH HHS K01 AR056734NIAMS NIH HHS P30 AR075055NIAMS NIH HHS R01 AR069670NIAMS NIH HHS R03 AR064004
6 · The paper itself

Abstract

Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and diabetes. High resolution peripheral quantitative computed tomography (HR-pQCT) enables in vivo microstructure characterization but is limited in its ability to visualize important biological features. We conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone fragility. These observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation.

Indexed as

Cortical bone porosityHR-pQCTType 2 diabetes

Identifiers

PMID37383338
PMCPMC10306320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.