ArticleOpen forum infectious diseases2023
Age Differences in Comorbidities, Presenting Symptoms, and Outcomes of Influenza Illness Requiring Hospitalization: A Worldwide Perspective From the Global Influenza Hospital Surveillance Network.
Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Influenza vaccine effectiveness according to frailty status in adults aged ≥ 50 years: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Oseltamivir Reduces 30-Day Mortality in Older Adults With Influenza: A Pooled Analysis From the 2012-2019 Serious Outcomes Surveillance Network of the Canadian Immunization Research Network.Open forum infectious diseases · 2025Trial
- Influenza infection influencing factors and direct economic burden - A study based on hospitalized cases of severe acute respiratory infection (SARI).Human vaccines & immunotherapeutics · 2026Article
- Disease burden associated with influenza activity at the population level.Epidemiology and infection · 2026Article
- Assessment of pre and postinfection immunity to the hemagglutinin proteins of Influenza A(H1N1)pdm09 and Influenza A(H3N2) in India: a retrospective longitudinal study.Virology journal · 2026Article
- Human Influenza Virus Infection: A Focus on Key Host Determinants Linked to Clinical Disease Severity.Viruses · 2026Review
- Article
- K-FluDB: a novel K-mer-based database for enhanced genomic surveillance of Influenza A viruses.Bioinformatics advances · 2026Article
- Limited Predictive Utility of Baseline Peripheral Blood Bulk Transcriptomics for Influenza Vaccine Responsiveness in Older Adults.Vaccines · 2025Article
- Impact of Obesity on Immunity to the Influenza Virus: Gut Microbiota, Mechanisms, and Novel Therapeutic Strategies.Diseases (Basel, Switzerland) · 2025Review
- Human Metapneumovirus Epidemiology Among Middle-aged and Older Adults Hospitalized With Acute Respiratory Infection.The Journal of infectious diseases · 2025Observational
- Relationship Between Frailty and Respiratory Syncytial Virus Infection in Hospitalized Older Adults.Open forum infectious diseases · 2025Article
- The Global Influenza Hospital Surveillance Network: A Multicountry Public Health Collaboration.Influenza and other respiratory viruses · 2025Article
- In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients.Health science reports · 2025Article
- Uptake of Influenza Vaccine among Older Adults with Cardiovascular Comorbidities.Arquivos brasileiros de cardiologia · 2025Article
- Comparative Analysis of Influenza Epidemiology Before and After the COVID-19 Pandemic in Argentina (2018-2019 vs. 2022-2023).Influenza and other respiratory viruses · 2025Article
- Spatiotemporal trends in severe complicated influenza among the local population in Taiwan region, 2003-2023.Epidemiology and health · 2025Article
- Predicting major clinical events among Canadian adults with laboratory-confirmed influenza infection using the influenza severity scale.Scientific reports · 2024Article
- The Hospital Burden of Flu in Italy: a retrospective study on administrative data from season 2014-2015 to 2018-2019.BMC infectious diseases · 2024Article
- Article
Corrections and comments
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Authors and funding
29 authors at 20 institutions in 20 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The Global Influenza Hospital Surveillance Network (GIHSN) was established in 2012 to conduct coordinated worldwide influenza surveillance. In this study, we describe underlying comorbidities, symptoms, and outcomes in patients hospitalized with influenza. Methods: Between November 2018 and October 2019, GIHSN included 19 sites in 18 countries using a standardized surveillance protocol. Influenza infection was laboratory-confirmed with reverse-transcription polymerase chain reaction. A multivariate logistic regression model was utilized to analyze the extent to which various risk factors predict severe outcomes. Results: Of 16 022 enrolled patients, 21.9% had laboratory-confirmed influenza; 49.2% of influenza cases were A/H1N1pdm09. Fever and cough were the most common symptoms, although they decreased with age ( Conclusions: Both virus and host factors contributed to influenza burden. We identified age differences in comorbidities, presenting symptoms, and adverse clinical outcomes among those hospitalized with influenza and benefit from influenza vaccination in protecting against adverse clinical outcomes. The GIHSN provides an ongoing platform for global understanding of hospitalized influenza illness.
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