Evidence map›Paper›PMID 37382748›Full record

Trial reportResearch on child and adolescent psychopathology2023

Single and Combined Effects of Multiple Intensities of Behavioral Modification and Methylphenidate for Children with ADHD in the Home Setting.

Brittany M Merrill, Fiona L Macphee, Lisa Burrows-MacLean, Erika K Coles, Brian T Wymbs, Anil Chacko, Kathryn Walker, Frances Wymbs, Allison Garefino, Jessica Robb Mazzant and 6 more

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Research on child and adolescent psychopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Brittany M MerrillCenter for Children and Families, Florida International University, Buffalo, NY, USA. brmerril@fiu.edu.ORCID 0000-0003-3844-8399
Fiona L MacpheeCenter for Children and Families, Florida International University, Miami, FL, 33199, USA.
Lisa Burrows-MacLeanState University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-9031-3208
Erika K ColesCenter for Children and Families, Florida International University, Miami, FL, 33199, USA.ORCID 0000-0001-5945-8313
Brian T WymbsDepartment of Psychology, Ohio University, Athens, OH, USA.ORCID 0000-0002-8530-5211
Anil ChackoDepartment of Applied Psychology, Steinhardt School of Culture, Education and Human Development, New York University, New York, NY, USA.ORCID 0000-0002-3275-4726
Kathryn WalkerThe Downtown Psychology Clinic, Toronto, ON, Canada.
Frances WymbsDepartment of Primary Care, Ohio University Heritage College of Osteopathic Medicine, Athens, OH, USA.ORCID 0000-0003-1855-0118
Allison GarefinoDepartment of Psychology, Kennesaw State University, Kennesaw, GA, USA.ORCID 0000-0002-2565-9552
Jessica Robb MazzantCenter for Children and Families, Florida International University, Miami, FL, 33199, USA.
Elizabeth M GnagyCenter for Children and Families, Florida International University, Miami, FL, 33199, USA.
James G WaxmonskyDepartment of Psychiatry, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, USA.ORCID 0000-0002-5563-3417
Greta M MassettiState University of New York at Buffalo, Buffalo, NY, USA.
Daniel A WaschbuschDepartment of Psychiatry, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, USA.
Gregory A FabianoCenter for Children and Families, Florida International University, Buffalo, NY, USA.ORCID 0000-0001-9029-8493
William E PelhamCenter for Children and Families, Florida International University, Miami, FL, 33199, USA. wpelham@fiu.edu.ORCID 0000-0002-3195-4478
Florida Department of Children and Families · USOhio University · USPennsylvania State University · USCenters for Disease Control and Prevention · USKennesaw State University · USNew York University · USUniversity at Buffalo, State University of New York · US

Funding

DEVELOPMENT OF ALCOHOL USE AND ABUSE IN ADHD ADOLESCENTSR01AA011873 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 1998 to 2007
$8.5M
The Development of Alcohol Use and Abuse in ADHD Adolescents and Young AdultsR37AA011873 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2008 to 2017
$7.9M
VALIDITY OF DSM-N SUBTYPES OF ADHD FOR YOUNG CHILDRENR01MH053554 · NIMH · UNIVERSITY OF CHICAGO · PI LAHEY, BENJAMIN B · 1995 to 2009
$4.2M
School Wide Prevention of Risk Factors for Drug AbuseR01DA012986 · NIDA · OREGON RESEARCH INSTITUTE · PI TAYLOR, TED K · 2001 to 2005
$3.0M
ECONOMIC ANALYSIS OF THE FAST TRACK INTERVENTIONR01MH062988 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FOSTER, EDWARD MICHAEL · 2002 to 2007
$2.8M
Development of Drug Use and Abuse in ADHD AdolescentsR01DA012414 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PELHAM, WILLIAM E · 2001 to 2012
$2.2M
ADHD Treatment:Comparative and Combined Dosage EffectsR01MH062946 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PELHAM, WILLIAM E · 2001 to 2004
$2.0M
Positive Illusions in ADHD: Processes and ConsequencesR01MH065899 · NIMH · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI HOZA, BETSY · 2004 to 2007
$1.7M
Increasing Academic Success in Middle School Students with ADHDR34MH092466 · NIMH · FLORIDA INTERNATIONAL UNIVERSITY · PI PELHAM, WILLIAM E, SIBLEY, MARGARET HARPER · 2012 to 2014
$636k
Living Arrangements, Parenting &Developmental OutcomesR01HD040935 · NICHD · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI JAYAKODY, RUKMALIE · 2001 to 2003
$529k
The Pittsburgh ADHD Longitudinal Study: Predicting alcohol misuse, problems, and disorder in mid-adulthoodR56AA011873 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2018 to 2018
$100k
NIAAA NIH HHS R01 AA011873NIAAA NIH HHS R37 AA011873NIAAA NIH HHS R56 AA011873NICHD NIH HHS R01 HD040935NIDA NIH HHS R01 DA012414NIDA NIH HHS R01 DA012986NIMH NIH HHS R01 MH053554NIMH NIH HHS R01 MH062946NIMH NIH HHS R01 MH062988NIMH NIH HHS R01 MH065899NIMH NIH HHS R34 MH092466
6 · The paper itself

Abstract

Behavioral treatment, stimulants, and their combination are the recommended treatments for childhood attention-deficit/hyperactivity disorder (ADHD). The current study utilizes within-subjects manipulations of multiple doses of methylphenidate (placebo, 0.15, 0.30, and 0.60 mg/kg/dose t.i.d.) and intensities of behavioral modification (no, low, and high intensity) in the summer treatment program (STP) and home settings. Outcomes are evaluated in the home setting. Participants were 153 children (ages 5-12) diagnosed with ADHD. In alignment with experimental conditions implemented during the STP day, parents implemented behavioral modification levels in three-week intervals, child medication status varied daily, and the orders were randomized. Parents provided daily reports of child behavior, impairment, and symptoms and self-reported parenting stress and self-efficacy. At the end of the study, parents reported treatment preferences. Stimulant medication led to significant improvements across all outcome variables with higher doses resulting in greater improvement. Behavioral treatment significantly improved child individualized goal attainment, symptoms, and impairment in the home setting and parenting stress and self-efficacy. Effect sizes indicate that behavioral treatment combined with a low-medium dose (0.15 or 0.30 mg/kg/dose) of medication results in equivalent or superior outcomes compared to a higher dose (0.60 mg/kg/dose) of medication alone. This pattern was seen across outcomes. Parents overwhelmingly reported preferring treatment with a behavioral component as a first-choice treatment (99%). Results underscore the need to consider dosing as well as parent preference when utilizing combined treatment approaches. This study provides further evidence that combining behavioral treatment and stimulant medication may reduce the stimulant dose needed for beneficial effects.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsMethylphenidateChildHumansParentingParentsCentral Nervous System StimulantsMethylphenidateADHDCombined treatmentMethylphenidateParent trainingTreatment preference

Identifiers

PMID37382748
PMCPMC11103974
OpenAlexW4382502821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.