Evidence map›Paper›PMID 37382655›Full record

ArticleEuropean journal of clinical pharmacology2023

Use of overactive bladder anticholinergic medications associated with falls leading to emergency department visits: results from the ADRED study.

Katja S Just, Karen A Schultze, Harald Dormann, Thomas Seufferlein, Ingo Gräff, Catharina Scholl, Matthias Schwab, Julia C Stingl

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Reducing Falls in Older Women with Urinary Incontinence.Advances in geriatric medicine and research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Katja S Just *Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Wendlingweg 2, D-52074, Aachen, Germany. kjust@ukaachen.de.ORCID http://orcid.org/0000-0002-6782-8078
Karen A Schultze *Institute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Wendlingweg 2, D-52074, Aachen, Germany.
Harald DormannCentral Emergency Department, Hospital Fürth, Fürth, Germany.
Thomas SeufferleinInternal Medicine Emergency Department, Ulm University Medical Centre, Ulm, Germany.
Ingo GräffInterdisciplinary Emergency Department (INZ), University Hospital of Bonn, Bonn, Germany.
Catharina SchollResearch Department, Federal Institute for Drugs and Medical Devices, Bonn, Germany.
Matthias SchwabDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
Julia C StinglInstitute of Clinical Pharmacology, University Hospital RWTH Aachen, Aachen, Wendlingweg 2, D-52074, Aachen, Germany.
RWTH Aachen University · DEDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology · DEFederal Institute for Drugs and Medical Devices · DEKlinikum Fürth · DEUniversitätsklinikum Aachen · DEUniversity Hospital Bonn · DE

Funding

Bundesministerium für Gesundheit ZMVI5-2514ATA004
6 · The paper itself

Abstract

purposeDrug intake might be a modifiable factor for the individual fall-risk of older adults, and anticholinergic properties of drugs need to be considered. This study is aimed at analyzing the association of older adults' individual anticholinergic load with particular focus on use of overactive bladder anticholinergic medications with falls in multi-medicated patients. MATERIALS AND

methodsCases of the prospective, observational, multi-center study on adverse drug reactions leading to emergency departments (ADRED study) between 2015 and 2018 in Germany were analyzed comparing the exposure of overactive bladder anticholinergic medications on the chance to present with a fall with patients without exposure. Logistic regression analysis was used adjusting for pre-existing conditions, drug exposure, and the individual anticholinergic burden by drug use. To this end, a combination of seven expert-based anticholinergic rating scales was used.

resultsThe anticholinergic burden was higher in patients with overactive bladder anticholinergic medications (median 2 [1; 3]) compared to not taking drugs of interest. Presenting with a fall was associated with overactive bladder anticholinergic medications (odds ratio (OR) 2.34 [95% confidence interval 1.14-4.82]). The use of fall-risk increasing drugs was likewise associated (OR 2.30 [1.32-4.00]). The anticholinergic burden itself seemed not to be associated with falls (OR 1.01 [0.90-1.12]).

conclusionsAlthough falls occur multifactorial in older adults and confounding by indication cannot be ruled out, the indication for a drug treatment should be decided with caution when other, non-pharmacological treatment options have been tried. GERMAN CLINICAL TRIAL REGISTER: DRKS-ID: DRKS00008979, registration date 01/11/2017.

Indexed as

Urinary Bladder, OveractiveAgedCholinergic AntagonistsEmergency Service, HospitalHumansProspective StudiesCholinergic AntagonistsAdverse drug reactionAnticholinergicFall-risk increasing drugsMulti-medicationOlder adultsOveractive bladder anticholinergic medicationsUrologicals

Identifiers

PMID37382655
PMCPMC10427532
OpenAlexW4382501289

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.