Influence of Pulsatility and Inflow Waveforms on Tracheal Airflow Dynamics in Healthy Older Adults.

Tracheal collapsibility is a dynamic process altering local airflow dynamics. Patient-specific simulation is a powerful technique to explore the physiological and pathological characteristics of human airways. One of the key considerations in implementing airway computations is choosing the right inlet boundary conditions that can act as a surrogate model for understanding realistic airflow simulations. To this end, we numerically examine airflow patterns under the influence of different profiles, i.e., flat, parabolic, and Womersley, and compare these with a realistic inlet obtained from experiments. Simulations are performed in ten patient-specific cases with normal and rapid breathing rates during the inhalation phase of the respiration cycle. At normal breathing, velocity and vorticity contours reveal primary flow structures on the sagittal plane that impart strength to cross-plane vortices. Rapid breathing, however, encounters small recirculation zones. Quantitative flow metrics are evaluated using time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI). Overall, the flow metrics encountered in a real velocity profile are in close agreement with parabolic and Womersley profiles for normal conditions, however, the Womersley inlet alone conforms to a realistic profile under rapid breathing conditions.