Evidence map›Paper›PMID 37382636›Full record

Trial reportPediatric cardiology2023

The Fontan Udenafil Exercise Longitudinal Trial: Subgroup Analysis.

David J Goldberg, Chenwei Hu, Adam M Lubert, Rahul H Rathod, Daniel J Penny, Christopher J Petit, Kurt R Schumacher, Salil Ginde, Richard V Williams, J K Yoon and 25 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02741115 (Fontan Udenafil Exercise Longitudinal Assessment Trial), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02741115 phase3completednot on this map

Fontan Udenafil Exercise Longitudinal Assessment Trial (FUEL)

TypeinterventionalSponsorMezzion Pharma Co. LtdRan2016 to 2019Enrolled400ConditionsSingle Ventricle Heart DiseaseArmsUdenafil, Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. How cardiac output is controlled in a Fontan circulation: an update.Interdisciplinary cardiovascular and thoracic surgery · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Five decades of Fontan palliation: What have we learned? What should we expect?The Journal of international medical research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 3 countries.

David J GoldbergDivision of Cardiology, The Children's Hospital of Philadelphia, Perelman School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA, 19104, USA. goldbergda@chop.edu.
Chenwei HuHealthCore, Watertown, MA, 02472, USA.
Adam M LubertCincinnati Children's Hospital and Medical Center, Heart Institute, Cincinnati, OH, 45229, USA.
Rahul H RathodDepartment of Cardiology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Daniel J PennyDivision of Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.
Christopher J PetitDivision of Pediatric Cardiology, Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, 10032, USA.
Kurt R SchumacherDivision of Cardiology, C.S. Mott Children's Hospital, Ann Arbor, MI, 48109, USA.
Salil GindeDivision of Cardiology, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI, 53226, USA.
Richard V WilliamsDivision of Pediatric Cardiology, University of Utah, Primary Children's Hospital, Salt Lake City, UT, 84132, USA.
J K YoonDepartment of Pediatrics, Sejong General Hospital, Bucheon, South Korea.
Gi Beom KimSeoul National University School of Medicine, Seoul National University Children's Hospital, Seoul, South Korea.
Todd T NowlenHeart Center, Phoenix Children's Hospital, Phoenix, AZ, 85016, USA.
Michael V DiMariaDepartment of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Benjamin P FrischhertzDivision of Cardiology, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Jonathan B WagnerDivisions of Cardiology and Clinical Pharmacology, Children's Mercy Kansas City, Kansas City, MO, 64108, USA.
Kimberly E McHughDivision of Pediatric Cardiology, Medical University of South Carolina, Charleston, SC, 29425, USA.
Brian W McCrindleDepartment of Pediatrics, The Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, Canada.
Mark J CartoskiNemours Cardiac Center, Nemours / Alfred I. DuPont Hospital for Children, Wilmington, DE, 19803, USA.
Jon A DetterichDivision of Cardiology, Children's Hospital Los Angeles, USC Keck School of Medicine, Los Angeles, CA, 90027, USA.
Anji T YetmanChildren's Hospital and Medical Center, University of Nebraska, Omaha, NE, 68114, USA.
Anitha S JohnDivision of Cardiology, Children's National Hospital, Washington, DC, 20010, USA.
Marc E RichmondDivision of Pediatric Cardiology, Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, 10032, USA.
Delphine YungDivision of Pediatric Cardiology, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA, 98105, USA.
R Mark PayneDivision of Cardiology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Andrew S MackieDivision of Cardiology, Stollery Children's Hospital, Edmonton, AB, T6G 2B7, Canada.
Christopher K DavisDivision of Cardiology, Rady Children's Hospital San Diego, University of California San Diego, San Diego, CA, 92123, USA.
Shabana ShahanavazDivision of Cardiology, St. Louis Children's Hospital, St. Louis, MO, 63110, USA.
Kevin D HillDuke Children's Pediatric and Congenital Heart Center, Durham, NC, 27705, USA.
Marisa AlmaguerCincinnati Children's Hospital and Medical Center, Heart Institute, Cincinnati, OH, 45229, USA.
Victor ZakHealthCore, Watertown, MA, 02472, USA.
Michael G McBrideDivision of Cardiology, The Children's Hospital of Philadelphia, Perelman School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA, 19104, USA.
Bryan H GoldsteinDivision of Cardiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, USA.
Gail D PearsonDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.
Stephen M ParidonDivision of Cardiology, The Children's Hospital of Philadelphia, Perelman School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA, 19104, USA.
Pediatric Heart Network Investigators
Children's Hospital of Philadelphia · USChildren's Hospital & Medical Center · USColumbia University Irving Medical Center · USAlfred I. duPont Hospital for Children · USBoston Children's Hospital · USChildren's Hospital Colorado · USChildren's Hospital of Los Angeles · USChildren's Hospital of Pittsburgh · USChildren's Mercy Hospital · USChildren's National · USCincinnati Children's Hospital Medical Center · USC. S. Mott Children's Hospital · USDuke Children's Hospital & Health Center · USMedical College of Wisconsin · USMedical University of South Carolina · USNational Heart Lung and Blood Institute · USPhoenix Children's Hospital · USRady Children's Hospital-San Diego · USRiley Hospital for Children · USSeattle Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Pediatric Heart Network's Fontan Udenafil Exercise Longitudinal (FUEL) Trial (Mezzion Pharma Co. Ltd., NCT02741115) demonstrated improvements in some measures of exercise capacity and in the myocardial performance index following 6 months of treatment with udenafil (87.5 mg twice daily). In this post hoc analysis, we evaluate whether subgroups within the population experienced a differential effect on exercise performance in response to treatment. The effect of udenafil on exercise was evaluated within subgroups defined by baseline characteristics, including peak oxygen consumption (VO

Indexed as

Oxygen ConsumptionSulfonamidesBenzenesulfonamidesChildExerciseExercise TestExercise ToleranceHumansPyrimidinesBenzenesulfonamidesPyrimidinesSulfonamidesudenafilExerciseFontanUdenafil

Identifiers

PMID37382636
OpenAlexW4382502789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.