ArticleeLife2023
A stable, distributed code for cue value in mouse cortex during reward learning.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
- Representations of the intrinsic value of information in mouse orbitofrontal cortex.Nature neuroscience · 2026Article
- Drug self-administration in head-fixed mice.Nature protocols · 2026Review
- Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Inherited input and local transformations shape the spatiotemporal organization of pathway specific striatal signals for motivated behavior.bioRxiv : the preprint server for biology · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- The Central Nucleus of the Amygdala Encodes the Motivation to Pursue Ethanol.bioRxiv : the preprint server for biology · 2026Article
- Population-level encoding of task information is stronger in the adolescent compared to adult frontal cortex.Developmental cognitive neuroscience · 2026Article
- Article
- A ventral tegmental area GABAergic projection to the ventral pallidum regulates value-based decision making in mice.bioRxiv : the preprint server for biology · 2026Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- VTA dopamine neuron activity produces spatially organized value representations.bioRxiv : the preprint server for biology · 2025Article
- Distributed Intracranial Activity Underlying Human Decision-making Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system.Current biology : CB · 2025Article
- Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex.Nature communications · 2024Article
- A persistent prefrontal reference frame across time and task rules.Nature communications · 2024Article
- A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging.Neuropharmacology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The ability to associate reward-predicting stimuli with adaptive behavior is frequently attributed to the prefrontal cortex, but the stimulus-specificity, spatial distribution, and stability of prefrontal cue-reward associations are unresolved. We trained head-fixed mice on an olfactory Pavlovian conditioning task and measured the coding properties of individual neurons across space (prefrontal, olfactory, and motor cortices) and time (multiple days). Neurons encoding cues or licks were most common in the olfactory and motor cortex, respectively. By quantifying the responses of cue-encoding neurons to six cues with varying probabilities of reward, we unexpectedly found value coding in all regions we sampled, with some enrichment in the prefrontal cortex. We further found that prefrontal cue and lick codes were preserved across days. Our results demonstrate that individual prefrontal neurons stably encode components of cue-reward learning within a larger spatial gradient of coding properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.