Evidence map›Paper›PMID 37382436›Full record

ArticlemBio2023

Mus musculus papillomavirus 1 E8^E2 represses expression of late protein E4 in basal-like keratinocytes via NCoR/SMRT-HDAC3 co-repressor complexes to enable wart formation

Franziska Kuehner, Margaret Wong, Elke Straub, John Doorbar, Thomas Iftner, Richard B S Roden, Frank Stubenrauch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Journal of virology · 2026
    Article
  4. bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Franziska KuehnerInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Eberhard-Karls University Tuebingen , Tuebingen, Germany.
Margaret WongDepartment of Pathology, The Johns Hopkins University , Baltimore, Maryland, USA.
Elke StraubInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Eberhard-Karls University Tuebingen , Tuebingen, Germany.
John DoorbarDepartment of Pathology, University of Cambridge , Cambridge, United Kingdom.ORCID 0000-0002-4027-102X
Thomas IftnerInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Eberhard-Karls University Tuebingen , Tuebingen, Germany.ORCID 0000-0002-5929-7078
Richard B S RodenDepartment of Pathology, The Johns Hopkins University , Baltimore, Maryland, USA.ORCID 0000-0002-2506-0195
Frank StubenrauchInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Eberhard-Karls University Tuebingen , Tuebingen, Germany.ORCID 0000-0002-6685-299X
University of Tübingen · DEJohns Hopkins University · USUniversity of Cambridge · GB

Funding

Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI Richard Bruce Roden · 2003 to 2026
$53.5M
Mouse modeling of HPV infectionR01CA233486 · NCI · JOHNS HOPKINS UNIVERSITY · PI HUNG, CHIEN-FU, RODEN, RICHARD BRUCE · 2019 to 2023
$3.0M
Development of Novel Spontaneous HPV Cervicovaginal Carcinoma Models for Cancer ImmunotherapyR01CA237067 · NCI · JOHNS HOPKINS UNIVERSITY · PI WU, TZYY-CHOOU · 2019 to 2023
$2.9M
Deutsche Forschungsgemeinschaft (DFG) Stu 218/5-1NCI NIH HHS P30CA06973NCI NIH HHS P50CA098252NCI NIH HHS R01 CA233486NCI NIH HHS R01 CA237067
6 · The paper itself

Abstract

High-risk human papillomaviruses (PV) account for approximately 600,000 new cancers per year. The early protein E8^E2 is a conserved repressor of PV replication, whereas E4 is a late protein that arrests cells in G2 and collapses keratin filaments to facilitate virion release. While inactivation of the Mus musculus PV1 (MmuPV1)

Indexed as

Histone DeacetylasesKeratinocytesNuclear Receptor Co-Repressor 1Nuclear Receptor Co-Repressor 2Oncogene Proteins, ViralPapillomaviridaeWartsAnimalsCo-Repressor ProteinsGene Expression Regulation, ViralHumansMiceVirus ReplicationCo-Repressor ProteinsHistone DeacetylasesNcor1 protein, mouseNcor2 protein, mouseNuclear Receptor Co-Repressor 1Nuclear Receptor Co-Repressor 2Oncogene Proteins, ViralE4E8^E2papillomavirusproductive replicationwart

Identifiers

PMID37382436
PMCPMC10470772
OpenAlexW4382502253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.