Evidence map›Paper›PMID 37382422›Full record

ArticleAIDS research and human retroviruses2024

Intracellular Islatravir-Triphosphate in Dried Blood Spots and Peripheral Blood Mononuclear Cells from Pig-Tailed Macaques.

Vincent Mainella, Mary Morrow, Kristina Brooks, Lane Bushman, Farah Abdelmawla, David Nerguizian, Ye Ji Choi, Dorothy Patton, Yvonne Cosgrove Sweeney, Sravan Kumar Patel and 2 more

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Vincent MainellaDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
Mary MorrowDepartment of Biostatistics and Bioinformatics, Colorado School of Public Health, Aurora, Colorado, USA.
Kristina BrooksDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
Lane BushmanDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
Farah AbdelmawlaDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
David NerguizianDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
Ye Ji ChoiDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
Dorothy PattonDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.
Yvonne Cosgrove SweeneyDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3892-9814
Sravan Kumar PatelDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Magee-Women's Research Institute, Pittsburgh, Pennsylvania, USA.
Peter AndersonDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-1200-8494
Lisa RohanDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Magee-Women's Research Institute, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1602-0172
University of Colorado Anschutz Medical Campus · USMagee-Womens Research Institute · USUniversity of Washington · USColorado School of Public Health · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
WaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI CHARLOTTE HOTCHKISS · 2012 to 2026
$34.4M
Long Acting Film Technology for Contraception and HIV Prevention (LATCH)R61AI142687 · NIAID · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ROHAN, LISA CENCIA · 2019 to 2021
$4.0M
Long Acting Film Technology for Contraception and HIV Prevention (LATCH)R33AI142687 · NIAID · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ROHAN, LISA CENCIA · 2022 to 2023
$2.1M
Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR)T32AI150547 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Joshua Adam Barocas, Kristine Mace Erlandson · 2020 to 2026
$1.3M
NIAID NIH HHS R33 AI142687NIAID NIH HHS R61 AI142687NIAID NIH HHS T32 AI150547NIH HHS P51 OD010425NIH HHS U42 OD011123
6 · The paper itself

Abstract

The purpose of this study was to evaluate the relationship between intracellular islatravir-triphosphate (ISL-TP) in paired peripheral blood mononuclear cells (PBMCs) and dried blood spots (DBS). Three pig-tailed macaques (PMs) were dosed with a single intravaginal extended-release ISL-etonogestrel film for a period of 31 days. After extraction and quantification, repeated measures correlation (r

Indexed as

Leukocytes, MononuclearMacaca nemestrinaAnimalsAnti-HIV AgentsDried Blood Spot TestingFemaleAnti-HIV AgentsadherenceEFdAextended-releasenonhuman primate modelNRTTIpharmacokineticspharmacology

Identifiers

PMID37382422
PMCPMC11295786
OpenAlexW4382501445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.