ArticleThe world journal of men's health2024
Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data.
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Article in The world journal of men's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26citing papers in PubMed, 1 pooled it
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surgical efficacy and predictors of outcome in varicocelectomy: a meta-analysis of multivariable studies.World journal of urology · 2025Pooled it
- Live Birth Rates After Varicocele Embolization in Patients After Failed In Vitro Fertilization With Intracytoplasmic Sperm Injection.Andrology · 2026Article
- Clinical Recommendations for the Management of Male Infertility: A Consensus from the Korean Society for Sexual Medicine and Andrology (KSSMA) Clinical Practice Guideline Committee.The world journal of men's health · 2026Review
- Preoperative Varicocele Severity and Sperm Concentration Are Associated with Absence of Internal Spermatic Vein Reflux in Patients Undergoing Varicocele Embolization: Results from A Cross-Sectional Study.The world journal of men's health · 2026Article
- Predictive parameters of semen outcome improvement after varicocele treatment by scleroembolization: a retrospective study.Journal of endocrinological investigation · 2026Article
- Semen Parameter Response to Varicocele Repair in Infertile Men With Cryptozoospermia.The Journal of urology · 2026Article
- Evaluation of the efficacy of subinguinal antegrade sclerotherapy and subinguinal micro varicocelectomy versus a combined approach on the semen parameters in infertile patients: a randomized prospective comparative study.Basic and clinical andrology · 2026Article
- Impact of Varicocele on Pregnancy and Live Birth Outcomes in Men with Clinical Varicocele: Systematic Review of Controlled Studies.The world journal of men's health · 2026Article
- Does the Quality and Readability of Information Related to Varicocele Obtained from ChatGPT 4.0 Remain Consistent Across Different Models of Inquiry?The world journal of men's health · 2026Article
- Global Andrology Forum (GAF) Clinical Guidelines on the Management of Infertile Men with Varicocele.The world journal of men's health · 2026Article
- Human teratozoospermia-related AGTPBP1 R791H mutation is associated with sperm head and tail defects in a CRISPR-engineered murine model.Journal of assisted reproduction and genetics · 2026Article
- Machine learning-based classification of varicocoele grading: A promising approach for diagnosis and treatment optimization.Andrology · 2025Article
- Reducing Quotation Errors in Scientific Manuscripts: A Novel Approach from the Global Andrology Forum.The world journal of men's health · 2025Article
- Impact of Varicocele Repair on Assisted Reproductive Technique Outcomes in Infertile Men: A Systematic Review and Meta-Analysis.The world journal of men's health · 2025Article
- Therapeutic Effects of Mesenchymal Stem Cell Conditioned Medium in Rat Varicocele Model.The world journal of men's health · 2025Article
- Challenging cases of adherent periarterial vein during subinguinal Fisch technique and subinguinal micro-varicocelecotmy and sclerotherapy: a prospective comparative study.Basic and clinical andrology · 2025Article
- Does age matter? Impact of age on testicular function and pregnancy outcomes following microsurgical varicocelectomy in patients with grade 3 varicocele.Arab journal of urology · 2025Article
- Research progress on the mechanism underlying the application of mesenchymal stem cells in the treatment of male infertility.Frontiers in endocrinology · 2025Review
- Enhancing Male Fertility Through AI-Based Management of Varicoceles.Current urology reports · 2024Review
- Comparison Between Varicocelectomy and Varicocele Sclerotherapy: Results of a Single-Center Observational Study.Life (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
145 authors.
Rossella CannarellaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0003-4599-8487
Rupin ShahDepartment of Urology, Lilavati Hospital and Research Centre, Mumbai, India.ORCID https://orcid.org/0000-0002-7868-5949
Taha Abo-Almagd Abdel-Meguid HamodaDepartment of Urology, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0002-8070-4088
Florence BoitrelleDepartment of Reproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France.ORCID https://orcid.org/0000-0002-5322-0141
Ramadan SalehDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.ORCID https://orcid.org/0000-0003-0503-3533
Murat GulDepartment of Urology, Selcuk University School of Medicine, Konya, Turkey.ORCID https://orcid.org/0000-0002-6657-6227
Amarnath RambhatlaDepartment of Urology, Henry Ford Health System, Vattikuti Urology Institute, Detroit, MI, USA.ORCID https://orcid.org/0000-0002-1383-6670
Parviz KavoussiDepartment of Reproductive Urology, Austin Fertility & Reproductive Medicine/Westlake IVF, Austin, TX, USA.ORCID https://orcid.org/0000-0001-7390-5837
Tuncay ToprakDepartment of Urology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-1348-5273
Ahmed M HarrazUrology and Nephrology Center, Mansoura University, Mansoura, Egypt.ORCID https://orcid.org/0000-0002-8902-517X
Edmund KoDepartment of Urology, Loma Linda University Health, Loma Linda, CA, USA.ORCID https://orcid.org/0000-0002-7465-3616
Gökhan ÇekerDepartment of Urology, Başakşehir Cam and Sakura City Hospital, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-7891-9450
Damayanthi DurairajanayagamDepartment of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia.ORCID https://orcid.org/0000-0001-9049-0215
Noora AlkahidiDepartment of Internal Medicine, Trinity Health/Mercy Health, Muskegon, MI, USA.ORCID https://orcid.org/0000-0003-1106-6606
Shinnosuke KurodaGlickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.ORCID https://orcid.org/0000-0001-8890-0297
Andrea CrafaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-8311-9095
Ralf HenkelDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-1128-2982
Gianmaria SalvioDepartment of Endocrinology, Polytechnic University of Marche, Ancona, Italy.ORCID https://orcid.org/0000-0001-9290-5699
Berk HazirReproductive Medicine, Clinical Research Centre, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-8907-8781
Mahsa DarbandiFetal Health Research Center, Hope Generation Foundation, Tehran, Iran.ORCID https://orcid.org/0000-0002-2243-9319
Marion BendayanDepartment of Reproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France.ORCID https://orcid.org/0000-0003-1633-7735
Sara DarbandiFetal Health Research Center, Hope Generation Foundation, Tehran, Iran.ORCID https://orcid.org/0000-0002-1868-6712
Marco FalconeDepartment of Urology, Molinette Hospital, A.O.U. Città della Salute e della Scienza, University of Turin, Torino, Italy.ORCID https://orcid.org/0000-0003-1101-892X
Nicolas GarridoIVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.ORCID https://orcid.org/0000-0001-8271-5218
Raghavender KosgiDepartment of Urology, Andrology and Renal Transplant, AIG Hospitals, Hyderabad, India.ORCID https://orcid.org/0000-0002-2178-0857
Raneen Sawaid KaiyalGlickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-3111-3978
Keshab KarnaDepartment of Molecular Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID https://orcid.org/0000-0003-1389-8975
Nguyen Ho Vinh PhuocDepartment of Andrology, Binh Dan Hospital, Ho Chi Minh, Vietnam.ORCID https://orcid.org/0000-0002-4348-6034
Ponco BirowoDepartment of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0003-2934-6753
Giovanni M ColpiAndrology and IVF Center, Next Fertility Procrea, Lugano, Switzerland.ORCID https://orcid.org/0000-0003-1431-1777
Jean de la RosetteDepartment of Urology, Istanbul Medipol Mega University Hospital, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-6308-1763
Germar-Michael PinggeraDepartment of Urology, Innsbruck Medical University, Innsbruck, Austria.ORCID https://orcid.org/0000-0001-6463-2494
Quang NguyenCenter for Andrology and Sexual Medicine, Viet Duc University Hospital, Hanoi, Vietnam.ORCID https://orcid.org/0000-0002-1670-8885
Armand ZiniDivision of Urology, Department of Surgery, McGill University, Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-2194-5578
Wael ZohdyDepartment of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-3100-929X
Rajender SinghCentral Drug Research Institute, Male Reproductive Health Research Laboratory, Lucknow, Uttar Pradesh, India.ORCID https://orcid.org/0000-0002-4592-6566
Pallavi SainiDivision of Endocrinology, Central Drug Research Institute, Lucknow, India.ORCID https://orcid.org/0000-0003-0072-5573
Sidney GlinaDivision of Urology, Centro Universitario FMABC, Santo André, Brazil.ORCID https://orcid.org/0000-0002-9053-5046
Haocheng LinDepartment of Urology, Peking University Third Hospital, Peking University, Beijing, China.ORCID https://orcid.org/0000-0002-5333-6611
Taymour MostafaDepartment of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-3627-0662
Cesar Rojas-CruzDepartment of Urology, University Hospital of Rostock, Rostock, Germany.ORCID https://orcid.org/0000-0002-3978-491X
Mohamed ArafaDepartment of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0107-8857
Aldo E CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0001-6950-335X
Fotios DimitriadisDepartment of Urology, Aristotle University School of Medicine, Thessaloniki, Greece.ORCID https://orcid.org/0000-0003-1198-9144
Priyank KothariDepartment of Urology, Topiwala National Medical College, B.Y.L Nair Ch Hospital, Mumbai, India.ORCID https://orcid.org/0000-0002-3940-952X
Vilvapathy Senguttuvan KarthikeyanAndrology Unit, Department of Urology, Apollo Hospitals, Greams Road, Chennai, India.ORCID https://orcid.org/0000-0002-0244-476X
Keisuke OkadaDepartment of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID https://orcid.org/0000-0002-2819-6047
Koji ChibaDepartment of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID https://orcid.org/0000-0001-5575-0667
Ates KadıogluDepartment of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-4239-7638
Baris AltayDepartment of Urology, Ege University, Izmir, Turkey.ORCID https://orcid.org/0000-0002-3101-8022
Tahsin TuruncUrocentre Urology Clinic, Adana, Turkey.ORCID https://orcid.org/0000-0002-7936-2172
Birute ZilaitieneInstitute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania, Turkey.ORCID https://orcid.org/0000-0002-4082-4843
Fatih GokalpDepartment of Urology, Faculty of Medicine, Hatay Mustafa Kemal University, Antakya, Hatay, Turkey.ORCID https://orcid.org/0000-0003-3099-3317
Aram AdamyanDepartment of Urology, Astghik Medical Center, Yerevan, Armenia.ORCID https://orcid.org/0000-0002-7213-7212
Darren KatzMen's Health Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0003-0861-5643
Eric ChungDepartment of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia.ORCID https://orcid.org/0000-0003-3373-3668
Tiago Cesar MierzwaDivision of Urology, Centro Universitario FMABC, Santo André, Brazil.ORCID https://orcid.org/0000-0001-7574-9540
Daniel Suslik ZylbersztejnFleury Group and Hospital Israelita Albert Einstein, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1481-0296
Gustavo Marquesine PaulDepartment of Clinical Surgery, Health Sciences Sector of the Federal University of Parana (UFPR), Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-5099-853X
Nikolaos SofikitisDepartment of Urology, Ioannina University School of Medicine, Ioannina, Greece.ORCID https://orcid.org/0000-0003-1528-4029
Ioannis Sokolakis2nd Department of Urology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID https://orcid.org/0000-0002-1938-8004
Vineet MalhotraSCM Clinic and Hospital, New Delhi, India.ORCID https://orcid.org/0000-0001-6760-0885
Sakti Ronggowardhana BrodjonegoroDivision of Urology, Department of Surgery, Prof. Dr. Sardjito Hospital, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.ORCID https://orcid.org/0000-0002-4091-2384
Ricky AdriansjahDepartment of Urology, Hasan Sadikin Hospital, Medical Faculty of Padjadjaran University, Bandung, Indonesia.ORCID https://orcid.org/0000-0002-9733-3092
Akira TsujimuraDepartment of Urology, Juntendo University Urayasu Hospital, Chiba, Japan.ORCID https://orcid.org/0000-0002-3821-5184
Toshiyasu AmanoDepartment of Urology, Nagano Red Cross Hospital, Nagano, Japan.ORCID https://orcid.org/0000-0002-9640-8718
Giancarlo BalerciaDepartment of Endocrinology, Polytechnic University of Marche, Ancona, Italy.ORCID https://orcid.org/0000-0003-1286-1521
Imad ZiouziouDepartment of Urology, College of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco.ORCID https://orcid.org/0000-0002-9844-6080
Isaac Ardianson DeswantoElang Medika Corpora Hospital, Tangerang, Indonesia.ORCID https://orcid.org/0000-0002-3816-5172
Marlon MartinezSection of Urology, Department of Surgery, University of Santo Tomas Hospital, Manila, Philippines.ORCID https://orcid.org/0000-0002-1191-8154
Hyun Jun ParkDepartment of Urology, Pusan National University School of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0003-0566-9574
Mustafa Emre BakırcıogluSENSART Clinic, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-2411-9703
Erman CeyhanDepartment of Urology, Baskent University Faculty of Medicine, Ankara, Turkey.ORCID https://orcid.org/0000-0001-8223-6399
Kaan AydosDepartment of Urology, Ankara University School of Medicine, Ankara, Turkey.ORCID https://orcid.org/0000-0001-7691-5459
Jonathan RamsayDepartment of Andrology, Hammersmith Hospital, Imperial, London, UK.ORCID https://orcid.org/0000-0002-2403-7698
Suks MinhasDepartment of Urology, Imperial Healthcare NHS Trust, Charing Cross Hospital, London, UK.ORCID https://orcid.org/0000-0001-6516-619X
Manaf Al HashimiDepartment of Urology, Burjeel Hospital, Abu Dhabi, UAE.ORCID https://orcid.org/0000-0002-2458-179X
Ramy Abou GhaydaInstitute of Urology, University Hospitals, Case Western Reserve University, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-5170-3983
Nicholas TadrosDivision of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID https://orcid.org/0000-0002-2272-235X
Puneet SindhwaniDepartment of Urology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.ORCID https://orcid.org/0000-0002-9420-2978
Christopher C K HoDepartment of Surgery, School of Medicine, Taylor's University, Subang Jaya, Selangor, Malaysia.ORCID https://orcid.org/0000-0002-8757-6867
Rinaldo Indra RachmanDepartment of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0003-4666-805X
Marcelo Rodriguez PenaInstituto de Ginecología y Fertilidad (IFER) y Universidad Barcelo, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0003-2437-7833
Ahmad MotawiDepartment of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0962-0604
Arun Karthik PonnusamyAndroOne Men's Health Clinic, Salem, India.ORCID https://orcid.org/0000-0002-6247-7256
Satish DipankarDepartment of Physiology, All India Institute of Medical Sciences Mangalagiri, Mangalagiri, India.ORCID https://orcid.org/0000-0002-8536-5804
Azwar AmirDepartment of Urology, Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia.ORCID https://orcid.org/0000-0003-4134-5593
Saleh BinsalehDivision of Urology, Department of Surgery, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0001-8946-4749
Ege Can SerefogluDepartment of Urology, Biruni University School of Medicine, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-2530-7012
Ravi BanthiaDepartment of Urology, Western General Hospital, Edinburgh, UK.ORCID https://orcid.org/0000-0001-8723-9732
Kareim KhalafallaDepartment of Urology, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0001-9476-4869
Ari BasukarnoDepartment of Urology, Dr. Dradjat Hospital, Serang, Indonesia.ORCID https://orcid.org/0000-0002-9580-7792
Nguyen Hoai BacDepartment of Andrology and Sexual Medicine, Hanoi Medical University's Hospital, Hanoi, Vietnam.ORCID https://orcid.org/0000-0003-1608-8812
Karun SinglaClarity Health, Chandigarh, India.ORCID https://orcid.org/0000-0003-2974-1075
Rafael F AmbarDivision of Urology, Centro Universitario FMABC, Santo André, Brazil.ORCID https://orcid.org/0000-0002-3496-2895
Konstantinos MakarounisDepartment of Urology and Andrology, Locus Medicus, Athens, Greece.ORCID https://orcid.org/0000-0002-3971-8330
Shivam PriyadarshiDepartment of Urology, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India.ORCID https://orcid.org/0000-0002-8521-6892
Gede Wirya Kusuma DuarsaDepartment of Urology, Prof. Dr. I.G.N.G Ngoerah General Hospital, Faculty of Medicine, Universitas Udayana, Bali, Indonesia.ORCID https://orcid.org/0000-0002-0642-159X
Widi AtmokoDepartment of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-7793-7083
Sunil JindalDepartment of Andrology & Reproductive Medicine, Jindal Hospital & Fertility Center, Meerut, India.ORCID https://orcid.org/0000-0002-8088-8710
Eko AriantoDepartment of Urology, Prof R.D. Kandou Hospital, Manado, Indonesia.ORCID https://orcid.org/0000-0002-1417-3928
Hamed AkhavizadeganUrology Department, Tehran University of Medical Scienes, Tehran, Iran.ORCID https://orcid.org/0000-0002-5432-7311
Haitham El BardisiDepartment of Urology, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0003-3902-7924
Ohad ShoshanyDepartment of Urology, University of Illinois at Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-4211-6277
Gian Maria BusettoDepartment of Urology and Renal Transplantation, Univeristy of Foggia, Foggia, Italy.ORCID https://orcid.org/0000-0002-7291-0316
Mohamad MoussaDepartment of Urology, Lebanese University, Beirut, Lebanon.ORCID https://orcid.org/0000-0001-8571-2768
Mounir JamaliDepartment of Urology, Military Teaching Hospital, Rabat, Morocco.ORCID https://orcid.org/0000-0003-1519-7363
Mohamed S Al-MarhoonDepartment of Surgery, Urology Division, Sultan Qaboos University, Muscat, Oman.ORCID https://orcid.org/0000-0002-8397-1560
Mikhail RuzaevUrology Clinic, Moscow, Russia.ORCID https://orcid.org/0000-0001-5258-2813
Hasan M A FarsiDepartment of Urology, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0002-1136-8623
Shingai MutambirwaDepartment of Urology, Dr. George Mukhari Academic Hospital, Sefako Makgatho Health Science University, Medunsa, Ga-Rankuwa, South Africa.ORCID https://orcid.org/0000-0003-1414-0218
Dong Sup LeeDepartment of Urology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-0862-3205
Deniz KulaksizDepartment of Obstetrics and Gynecology, University of Health Sciences, Kanuni Training and Research Hospital, Trabzon, Turkey.ORCID https://orcid.org/0000-0003-2351-1367
Yu-Sheng ChengDepartment of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-3981-8657
Abderrazak BouzouitaDepartment of Anatomy, Faculty of Medicine, Faculty Tunis Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0001-9644-0745
Selcuk SarikayaDepartment of Urology, Gulhane Research and Training Hospital, University of Health Sciences, Ankara, Turkey.ORCID https://orcid.org/0000-0001-6426-1398
Hussein KandilFakih IVF Fertility Center, Abu Dhabi, UAE.ORCID https://orcid.org/0000-0002-5549-3274
Georgios TsampoukasDepartment of Urology, Oxford University Hospital, Oxford, UK.ORCID https://orcid.org/0000-0002-2340-7343
Ala'a FarkouhGlobal Andrology Forum, Moreland Hills, OH, USA.ORCID https://orcid.org/0000-0002-0362-9109
Kasonde BowaDepartment of Urology, School of Medicine and Health Sciences, University of Lusaka, Lusaka, Zambia.ORCID https://orcid.org/0000-0001-7032-7998
Missy SaviraDepartment of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-7793-7083
Nasser MogharabianSexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.ORCID https://orcid.org/0000-0001-8795-973X
Tan V LeDepartment of Andrology, Binh Dan Hospital, Ho Chi Minh, Vietnam.ORCID https://orcid.org/0000-0003-1766-7453
Maruto HarjanggiIVF Jakarta - YPK Mandiri, Jakarta, Indonesia.ORCID https://orcid.org/0000-0001-6137-7053
Dang Tuan AnhTam Anh IVF Center, Tam Anh General Hospital, Hanoi, Vietnam.ORCID https://orcid.org/0000-0002-2317-6493
Tran Quang Tien LongDepartment of Obstetrics and Gynecology, Hanoi Obstetric and Gynecology Hospital, Hanoi, Vietnam.ORCID https://orcid.org/0000-0001-8905-3130
Mohammad Ayodhia SoebadiDepartment of Urology, Soetomo Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID https://orcid.org/0000-0003-2605-1263
Lukman HakimDepartment of Urology, Universitas Airlangga Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID https://orcid.org/0000-0003-1518-8010
Marko TanicDepartment of Urology, General Hospital, Cuprija, Serbia.ORCID https://orcid.org/0000-0002-5159-2128
Umut Cagin AriDepartment of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey.ORCID https://orcid.org/0000-0002-7089-6522
Firuza R ParikhFertilTree-Jaslok International Fertility Centre, Jaslok Hospital, Mumbai, Maharashtra, India.ORCID https://orcid.org/0000-0001-5267-8786
Gokhan CalikDepartment of Urology, Istanbul Medipol Mega University Hospital, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-9976-9666
Vinod KvCure & SK Hospital, Trivandrum, India.ORCID https://orcid.org/0000-0002-0346-8974
Gyem DorjiDepartment of Anatomy, Khesar Gyalpo University of Medical Sciences of Bhutan, Thimphu, Bhutan.ORCID https://orcid.org/0000-0002-3606-5151
Andri RezanoAndrology Study Program, Department of Biomedical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.ORCID https://orcid.org/0000-0003-2550-8794
Osvaldo RajmilDepartment of Andrology, Fundacio Puigvert, Barcelona, Spain.ORCID https://orcid.org/0000-0003-1987-9206
Dung Mai Ba TienDepartment of Andrology, Binh Dan Hospital, Ho Chi Minh, Vietnam.ORCID https://orcid.org/0000-0001-8605-2968
Yiming YuanDepartment of Urology, Peking University Third Hospital, Peking University, Beijing, China.ORCID https://orcid.org/0000-0002-8312-0723
Juan Francisco Lizarraga-SalasInstituto de Ciencias en Reproducción Humana Vida, León, Mexico.ORCID https://orcid.org/0000-0003-2800-4890
Balantine EzeDepartment of Surgery, College of Medicine, Enugu State University of Science and Technology, Enugu, Nigeria.ORCID https://orcid.org/0000-0001-8341-4943
Kay Seong NgooUrology Unit, Department of Surgery, Hospital Angkatan Tentera Tuanku Mizan, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0003-2787-3963
Joe LeeDepartment of Urology, National University Hospital, Singapore.ORCID https://orcid.org/0000-0003-0997-2757
Umut ArslanDepartment of Urology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-3862-3644
Ashok AgarwalDepartment of Urology, School of Medicine and Health Sciences, University of Lusaka, Lusaka, Zambia.ORCID https://orcid.org/0000-0003-0585-1026
Global Andrology Forum
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. MATERIALS AND
methodsThe meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies).
resultsOut of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864.
conclusionsThe current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.
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Controlled before-after studiesInfertility, maleMeta-analysisVaricocele
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.