Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors at 4 institutions in 2 countries.
Gaokun QiuMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID 0000-0002-9106-6747
Yuhui LinMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID 0000-0003-3280-4065
Yang OuyangCAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China.ORCID 0000-0002-6652-1779
Mingrong YouDivision of Epidemiology, Department of Medicine Vanderbilt University Medical Center Nashville TN.ORCID 0000-0001-7315-8405
Xinjie ZhaoCAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China.
Hao WangMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Rundong NiuMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Wending LiMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Xuedan XuMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Qi YanMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Yurong LiuMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID 0000-0002-1526-8953
Yingmei LiMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID 0000-0003-2322-2389
Handong YangDepartment of Cardiovascular Disease, Sinopharm Dongfeng Central Hospital Hubei University of Medicine Shiyan China.
Xiulou LiDepartment of Cardiovascular Disease, Sinopharm Dongfeng Central Hospital Hubei University of Medicine Shiyan China.ORCID 0000-0002-5917-1002
Meian HeMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Xiaomin ZhangMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID 0000-0003-3877-5242
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine Vanderbilt University Medical Center Nashville TN.ORCID 0000-0002-0711-8314
Guowang XuCAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China.ORCID 0000-0003-4298-3554
Tangchun WuMinistry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID 0000-0001-9931-5106
Huazhong University of Science and Technology · CNDalian Institute of Chemical Physics · CNHubei University of Medicine · CNVanderbilt University Medical Center · US
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Background This study was performed to identify metabolites associated with incident acute coronary syndrome (ACS) and explore causality of the associations. Methods and Results We performed nontargeted metabolomics in a nested case-control study in the Dongfeng-Tongji cohort, including 500 incident ACS cases and 500 age- and sex-matched controls. Three metabolites, including a novel one (aspartylphenylalanine), and 1,5-anhydro-d-glucitol (1,5-AG) and tetracosanoic acid, were identified as associated with ACS risk, among which aspartylphenylalanine is a degradation product of the gut-brain peptide cholecystokinin-8 rather than angiotensin by the angiotensin-converting enzyme (odds ratio [OR] per SD increase [95% CI], 1.29 [1.13-1.48]; false discovery rate-adjusted
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Nontargeted Metabolomics Revealed Novel Association Between Serum Metabolites and Incident Acute Coronary Syndrome: A Mendelian Randomization Study. · full record | OpenQuestion