Evidence map›Paper›PMID 37382105›Full record

ArticleJournal of the American Heart Association2023

Left Ventricular Physiology and Ventricular-Vascular Interactions in Young Patients After Heart Transplantation.

Heiner Latus, Ramona Raap, Karin Klingel, Christoph Happel, Axel Moysich, Markus Khalil, Gunter Kerst, Jakob Milla, Susanne Skrzypek, Josef Thul and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Heiner LatusPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.ORCID 0000-0003-3939-6025
Ramona RaapPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.
Karin KlingelCardiopathology Institute for Pathology and Neuropathology, University Hospital Tübingen Tübingen Germany.ORCID 0000-0003-0203-2498
Christoph HappelPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.ORCID 0000-0002-1010-4327
Axel MoysichPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.
Markus KhalilPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.
Gunter KerstPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.ORCID 0000-0002-2359-5612
Jakob MillaCardiopathology Institute for Pathology and Neuropathology, University Hospital Tübingen Tübingen Germany.
Susanne SkrzypekPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.
Josef ThulPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.
Christian JuxPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.
Dietmar SchranzPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.ORCID 0000-0003-4559-9021
Christian ApitzPediatric Heart Centre, Centre for Congenital Heart Disease Giessen Germany.ORCID 0000-0002-6780-8077
Deutsches Herzzentrum München · DEUniversity Children's Hospital Tübingen · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background In patients after heart transplantation, systemic arterial hypertension and enhanced central aortic stiffness contribute to increased ventricular afterload, which might lead to graft dysfunction. The aim of our study was to characterize systemic arterial elastance and its impact on left ventricular function and ventriculo-arterial coupling in a cohort of children, adolescents, and young adults after heart transplantation using invasive conductance catheter technique. Methods and Results Thirty patients who had heart transplants (age, 20.0±6.5 years, 7 female) underwent invasive cardiac catheterization including pressure-volume loop analysis. Load-independent parameters of systolic (ventricular elastance [Ees]) and diastolic (ventricular compliance) function as well as systemic arterial elastance (Ea, end-systolic pressure/stroke volume) and ventriculo-arterial coupling (Ea/Ees) were assessed at baseline level and during dobutamine infusion (10 μg/kg/min). Ees showed an appropriate increase under inotropic stimulation from 0.43 (0.11-2.52) to 1.00 (0.20-5.10) mm Hg/mL/m

Indexed as

Heart FailureHeart TransplantationAdolescentAdultChildDobutamineFemaleHeart VentriclesHumansStroke VolumeVentricular Function, LeftYoung AdultDobutamineheart transplantationpressure‐volume loopsventricular dysfunction

Identifiers

PMID37382105
PMCPMC10356064
OpenAlexW4382501372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.