Evidence map›Paper›PMID 37382101›Full record

ArticleJournal of the American Heart Association2023

Risk of Cardiovascular Disease After COVID-19 Diagnosis Among Adults With and Without Diabetes.

Alain K Koyama, Giuseppina Imperatore, Deborah B Rolka, Elizabeth Lundeen, Rachel E Rutkowski, Sandra L Jackson, Siran He, Elena V Kuklina, Soyoun Park, Meda E Pavkov

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. COVID-19 and Diabetes: Clinical Symptoms, Acute Kidney Injury, Inflammatory Response, and Poor Prognosis Factors.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Alain K KoyamaDivision of Diabetes Translation Centers for Disease Control and Prevention Atlanta GA USA.ORCID 0000-0002-1246-2937
Giuseppina ImperatoreDivision of Diabetes Translation Centers for Disease Control and Prevention Atlanta GA USA.
Deborah B RolkaDivision of Diabetes Translation Centers for Disease Control and Prevention Atlanta GA USA.ORCID 0000-0001-8732-8882
Elizabeth LundeenDivision of Diabetes Translation Centers for Disease Control and Prevention Atlanta GA USA.
Rachel E RutkowskiDivision of Diabetes Translation Centers for Disease Control and Prevention Atlanta GA USA.ORCID 0000-0001-7754-6042
Sandra L JacksonDivision for Heart Disease and Stroke Prevention Centers for Disease Control and Prevention Atlanta GA USA.
Siran HeDivision for Heart Disease and Stroke Prevention Centers for Disease Control and Prevention Atlanta GA USA.ORCID 0000-0002-0452-355X
Elena V KuklinaDivision for Heart Disease and Stroke Prevention Centers for Disease Control and Prevention Atlanta GA USA.ORCID 0000-0002-9686-6495
Soyoun ParkDivision for Heart Disease and Stroke Prevention Centers for Disease Control and Prevention Atlanta GA USA.ORCID 0000-0003-1862-6370
Meda E PavkovDivision of Diabetes Translation Centers for Disease Control and Prevention Atlanta GA USA.
Centers for Disease Control and Prevention · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Growing evidence suggests incident cardiovascular disease (CVD) may be a long-term outcome of COVID-19 infection, and chronic diseases, such as diabetes, may influence CVD risk associated with COVID-19. We evaluated the postacute risk of CVD >30 days after a COVID-19 diagnosis by diabetes status. Methods and Results We included adults ≥20 years old with a COVID-19 diagnosis from March 1, 2020 through December 31, 2021 in a retrospective cohort study from the IQVIA PharMetrics Plus insurance claims database. A contemporaneous control group comprised adults without recorded diagnoses for COVID-19 or other acute respiratory infections. Two historical control groups comprised patients with or without an acute respiratory infection. Cardiovascular outcomes included cerebrovascular disorders, dysrhythmia, inflammatory heart disease, ischemic heart disease, thrombotic disorders, other cardiac disorders, major adverse cardiovascular events, and any CVD. The total sample comprised 23 824 095 adults (mean age, 48.4 years [SD, 15.7 years]; 51.9% women; mean follow-up, 8.5 months [SD, 5.8 months]). In multivariable Cox regression models, patients with a COVID-19 diagnosis had a significantly greater risk of all cardiovascular outcomes compared with patients without a diagnosis of COVID-19 (hazard ratio [HR], 1.66 [1.62-1.71], with diabetes; HR, 1.75 [1.73-1.78], without diabetes). Risk was attenuated but still significant for the majority of outcomes when comparing patients with COVID-19 to both historical control groups. Conclusions In patients with COVID-19 infection, postacute risk of incident cardiovascular outcomes is significantly higher than among controls without COVID-19, regardless of diabetes status. Therefore, monitoring for incident CVD may be essential beyond the first 30 days after a COVID-19 diagnosis.

Indexed as

Cardiovascular DiseasesCOVID-19Diabetes MellitusHeart DiseasesAdultCOVID-19 TestingFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsYoung Adultcardiovascular diseaseCOVID‐19diabetes

Identifiers

PMID37382101
PMCPMC10356070
OpenAlexW4382501405

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.