Evidence map›Paper›PMID 37381923›Full record

ArticleCirculation. Heart failure2023

Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling.

Anne-Mar van Ommen, Ernest Diez Benavente, N Charlotte Onland-Moret, Gideon B Valstar, Maarten J Cramer, Frans H Rutten, Arco J Teske, Roxana Menken, Leonard Hofstra, Igor I Tulevski and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Interferons and interferon-related pathways in heart disease.Frontiers in cardiovascular medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Anne-Mar van OmmenLaboratory of Experimental Cardiology (A.-M.v.O., E.D.B., G.B.V., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0003-1249-0767
Ernest Diez BenaventeLaboratory of Experimental Cardiology (A.-M.v.O., E.D.B., G.B.V., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0002-4313-4290
N Charlotte Onland-MoretDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care (N.C.O.-M., F.H.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0002-2360-913X
Gideon B ValstarLaboratory of Experimental Cardiology (A.-M.v.O., E.D.B., G.B.V., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.
Maarten J CramerClinical Cardiology Department (M.J.C., A.J.T.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0002-6041-6759
Frans H RuttenDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care (N.C.O.-M., F.H.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0002-5052-7332
Arco J TeskeClinical Cardiology Department (M.J.C., A.J.T.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0001-5305-1619
Roxana MenkenCardiology Centers of the Netherlands (R.M., L.H., I.I.T., G.A.S.).ORCID 0000-0002-6314-9238
Leonard HofstraCardiology Centers of the Netherlands (R.M., L.H., I.I.T., G.A.S.).ORCID 0000-0003-4432-4720
Igor I TulevskiCardiology Centers of the Netherlands (R.M., L.H., I.I.T., G.A.S.).
Nancy SweitzerDepartment of Medicine, Washington University School of Medicine, St. Louis, MO (N.S.).ORCID 0000-0002-8117-6678
G Aernout Somsen *Cardiology Centers of the Netherlands (R.M., L.H., I.I.T., G.A.S.).ORCID 0000-0001-5690-4429
Hester M den Ruijter *Laboratory of Experimental Cardiology (A.-M.v.O., E.D.B., G.B.V., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0001-9762-014X
Utrecht University · NLThe Centers · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConcentric remodeling (cRM) can precede heart failure with preserved ejection fraction (HFpEF), a condition prevalent in women.

methodsPatients (n=60 593, 54.2% women) visiting outpatient clinics of Cardiology Centers of the Netherlands were analyzed for cRM, HFpEF development, and mortality risk. We studied risk factors for relative wall thickness both sex-stratified and in women and men combined. Biomarker profiling was performed (4534 plasma proteins) in a substudy involving 557 patients (65.4% women) to identify pathways involved in cRM.

resultscRM was present in 23.5% of women and 27.6% of men and associated with developing HFpEF (HR, 2.15 [95% CI, 1.51-2.99]) and mortality risk (HR, 1.09 [95% CI, 1.00-1.19]) in both sexes. Age, heart rate, and hypertension were statistically significantly stronger risk factors for relative wall thickness in women than men. Higher circulating levels of IFNA5 (interferon alpha-5) were associated with higher relative wall thickness in women only. Pathway analysis revealed differential pathway activation by sex and increased expression of inflammatory pathways in women.

conclusionscRM is prevalent in approximately 1 in 4 women and men visiting outpatient cardiology clinics and associated with HFpEF development and mortality risk in both sexes. Known risk factors for cRM were more strongly associated in women than men. Proteomic analysis revealed inflammatory pathway activation in women, with a central role for IFNA5. Differential biologic pathway activation by sex in cRM may contribute to the female predominance of HFpEF and holds promise for identification of new therapeutic avenues for prevention and treatment of HFpEF. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT001747.

Indexed as

Heart FailureFemaleHumansMalePrognosisProteomicsSex CharacteristicsStroke VolumeVentricular Function, LeftVentricular Remodelingechocardiographyheart failureinterferonsprevention & controlprognosisproteomicssex characteristics

Identifiers

PMID37381923
PMCPMC10348648
OpenAlexW4382502819

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.