Evidence map›Paper›PMID 37381756›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Rational repurposing, synthesis,

Ahmed H E Hassan, Waleed A Bayoumi, Selwan M El-Sayed, Trong-Nhat Phan, Yeon Ju Kim, Chae Hyeon Lee, Soo Bin Cho, Taegeun Oh, Gyeongpyo Ham, Kazem Mahmoud and 2 more

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ahmed H E HassanDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.ORCID 0000-0002-1048-6281
Waleed A BayoumiDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.ORCID 0000-0002-6761-9612
Selwan M El-SayedDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.ORCID 0000-0003-3962-6409
Trong-Nhat PhanHost-Parasite Research Laboratory, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.ORCID 0000-0002-4696-7490
Yeon Ju KimDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Chae Hyeon LeeDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Soo Bin ChoDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Taegeun OhDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Gyeongpyo HamDepartment of Fundamental Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Kazem MahmoudDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt.ORCID 0000-0002-7044-0015
Joo Hwan NoHost-Parasite Research Laboratory, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
Yong Sup LeeMedicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.ORCID 0000-0001-6523-6979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A chromone-peptidyl hybrids series was synthesised and rationally repurposed towards identification of potential antileishmanial hits against visceral leishmaniasis. Three hybrids

Indexed as

Leishmania donovaniLeishmaniasis, VisceralChromonesHumansOrganophosphatesPhosphorylcholineQuaternary Ammonium CompoundsChromoneserucylphospho-N,N,N-trimethylpropylammoniummiltefosineOrganophosphatesPhosphorylcholineQuaternary Ammonium CompoundsAntileishmanial agentsChromoneLeishmania donovaniPromastigotesRepurposingVisceral Leishmaniasis

Identifiers

PMID37381756
PMCPMC10312039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.