ArticleOptics express2023
Pulsed stimulated Brillouin microscopy.
Article in Optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07780890 (A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases
Who cites it
8 citing papers in PubMed.
- Brillouin microscopy for contact- and label-free quantification of tissue stiffness in lung fibrosis.American journal of respiratory cell and molecular biology · 2026Article
- Review
- Laser-emission vibrational microscopy of microdroplet arrays for high-throughput screening of hyperlipidemia.Light, science & applications · 2025Article
- Improvement of gain and spatial resolution for impulsive stimulated Brillouin scattering microscopy.Photoacoustics · 2025Article
- Full-field Brillouin microscopy based on an imaging Fourier-transform spectrometer.Nature photonics · 2025Article
- Impact of polarization pulling on optimal spectrometer design for stimulated Brillouin scattering microscopy.APL photonics · 2024Article
- Current state of stimulated Brillouin scattering microscopy for the life sciences.JPhys photonics · 2024Review
- Brillouin microscopy.Nature reviews. Methods primers · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Stimulated Brillouin scattering is an emerging technique for probing the mechanical properties of biological samples. However, the nonlinear process requires high optical intensities to generate sufficient signal-to-noise ratio (SNR). Here, we show that the SNR of stimulated Brillouin scattering can exceed that of spontaneous Brillouin scattering with the same average power levels suitable for biological samples. We verify the theoretical prediction by developing a novel scheme using low duty cycle, nanosecond pulses for the pump and probe. A shot noise-limited SNR over 1000 was measured with a total average power of 10 mW for 2 ms or 50 mW for 200 µs integration on water samples. High-resolution maps of Brillouin frequency shift, linewidth, and gain amplitude from cells in vitro are obtained with a spectral acquisition time of 20 ms. Our results demonstrate the superior SNR of pulsed stimulated Brillouin over spontaneous Brillouin microscopy.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.