ArticleOptics express2023
Functional imaging through scattering medium via fluorescence speckle demixing and localization.
Article in Optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Methods, Trade-offs, and Opportunities in High-speed Optical Microscopy for Neural Voltage imaging.Nature photonics · 2026Article
- Intensity-correlation synthetic wavelength imaging in dynamic scattering media.Nature communications · 2026Article
- Foveated light-field compound imager.Science advances · 2026Article
- Foveated Light-Field Compound Imager.bioRxiv : the preprint server for biology · 2026Article
- Fluorescence microscopy through scattering media with robust matrix factorization.Cell reports methods · 2025Article
- Neurophotonics beyond the surface: unmasking the brain's complexity exploiting optical scattering.Neurophotonics · 2024Article
- Implantable photonic nano-modulators open perspectives for advanced optical interfaces with deep brain areas.Neurophotonics · 2024Article
- Demixing fluorescence time traces transmitted by multimode fibers.Nature communications · 2024Article
- Speckle-enabled in vivo demixing of neural activity in the mouse brain.Biomedical optics express · 2024Article
- Neurophotonics beyond the Surface: Unmasking the Brain's Complexity Exploiting Optical Scattering.ArXiv · 2024Article
- Single-pixel transmission matrix recovery via two-photon fluorescence.Science advances · 2024Article
- Roadmap on computational methods in optical imaging and holography [invited].Applied physics. B, Lasers and optics · 2024Review
- Functional imaging through scattering medium via fluorescence speckle demixing and localization.Optics express · 2023Article
- Functional imaging through scattering medium via fluorescence speckle demixing and localization.ArXiv · 2023Article
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6 authors.
Funding
Abstract
Recently, fluorescence-based optical techniques have emerged as a powerful tool to probe information in the mammalian brain. However, tissue heterogeneities prevent clear imaging of deep neuron bodies due to light scattering. While several up-to-date approaches based on ballistic light allow to retrieve information at shallow depths inside the brain, non-invasive localization and functional imaging at depth still remains a challenge. It was recently shown that functional signals from time-varying fluorescent emitters located behind scattering samples could be retrieved by using a matrix factorization algorithm. Here we show that the seemingly information-less, low-contrast fluorescent speckle patterns recovered by the algorithm can be used to locate each individual emitter, even in the presence of background fluorescence. We test our approach by imaging the temporal activity of large groups of fluorescent sources behind different scattering phantoms mimicking biological tissues, and through a brain slice with a thickness of ∼200 µm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.