Evidence map›Paper›PMID 37381060›Full record

ArticleCell & bioscience2023

Spatiotemporal control of genome engineering in cone photoreceptors.

Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Yun-Ju Tseng, Laura A Jenny, Nicholas D Nolan, Nelson Chen, Hung-Hsi Wang, Chun Wei Hsu, Wan-Chun Huang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell & bioscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Nan-Kai Wang *Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA. wang.nankai@gmail.com.
Pei-Kang Liu *Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Yang KongEdward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Yun-Ju TsengEdward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Laura A JennyEdward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Nicholas D NolanEdward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Nelson ChenEdward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Hung-Hsi WangEdward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Chun Wei HsuEdward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Wan-Chun HuangEdward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Janet R SparrowDepartments of Ophthalmology, Pathology and Cell Biology, Columbia University, New York, USA.
Chyuan-Sheng LinDepartment of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Stephen H TsangEdward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, 10032, USA. sht2@cumc.columbia.edu.
Columbia University Irving Medical Center · USColumbia University · USNational Sun Yat-sen University · TW

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
Reprogramming the metabolome to overcome the genetic heterogeneity in retinitis pigmentosaR01EY031354 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, NAN-KAI · 2020 to 2024
$2.0M
NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY031354
6 · The paper itself

Abstract

backgroundCones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to developing therapies for retinal diseases. However, studying the biology of cone cells in the rod-dominant mammalian retina is particularly challenging. In this study, we used a bacterial artificial chromosome (BAC) recombineering method to knock in the "CreER

resultsThese models (Gnat2

conclusionsThe Arr3

Indexed as

2A peptideArrestin 3Cone arrestinCreERT2Cre-LoxP recombination

Identifiers

PMID37381060
PMCPMC10304375
OpenAlexW4382502181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.