Evidence map›Paper›PMID 37380958›Full record

ArticleBMC anesthesiology2023

Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat.

Fengru Guo, Yuqin Li, Zhaoxin Jian, Yan Cui, Wenhui Gong, Airui Li, Wei Jing, Peng Xu, Ke Chen, Daqing Guo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Fengru Guo *Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Yuqin Li *Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Zhaoxin JianDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Yan CuiDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Wenhui GongDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Airui LiDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Wei JingDepartment of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 4030030, China.
Peng XuDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Ke ChenDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Daqing GuoDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Dezhong YaoDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Yang XiaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China. xiayang@uestc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed.

methodsWe implanted electrodes in brain regions of the rat DMN to acquire local field potentials to investigate the perturbations produced by anesthesia. Relative power spectral density, static functional connectivity (FC), fuzzy entropy of dynamic FC, and topological features were computed from the data.

resultsThe results showed that adaptive reconstruction was induced by isoflurane, exhibiting reduced static and stable long-range FC, and altered topological features. These reconstruction patterns were in a dose-related fashion.

conclusionThese results might impart insights into the neural network mechanisms underlying anesthesia and suggest the potential of monitoring the depth of anesthesia based on the parameters of DMN.

Indexed as

AnesthesiaAnesthesiologyIsofluraneAnimalsElectrodesEntropyRatsIsofluraneDefault mode networkIsoflurane

Identifiers

PMID37380958
PMCPMC10303294

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