Evidence map›Paper›PMID 37380814›Full record

ArticleVirus genes2023

Peptide YY inhibits transcription and replication of hepatitis B virus by suppressing promoter/enhancer activity.

Xiaolun Xu, Weiping Zhou, Xing Tian, Zhongjia Jiang, Xuanhe Fu, Jun Cao, Ye Sun, Biao Yang, Xueqian Li, Yanting Li and 2 more

Abstract read
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In one paragraph

Article in Virus genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Xiaolun Xu *Department of Pathogen Biology, Shenyang Medical College, Shenyang, China.
Weiping Zhou *Department of Pathogen Biology, Shenyang Medical College, Shenyang, China.
Xing TianDepartment of Physiology, Shenyang Medical College, Shenyang, China.
Zhongjia JiangDepartment of Biochemistry and Molecular Biology, Shenyang Medical College, Shenyang, China.
Xuanhe FuDepartment of Immunology, Shenyang Medical College, Shenyang, China.
Jun CaoDepartment of Pathogen Biology, Shenyang Medical College, Shenyang, China.
Ye SunDepartment of Pathogen Biology, Shenyang Medical College, Shenyang, China.
Biao YangDepartment of Pathogen Biology, Shenyang Medical College, Shenyang, China.
Xueqian LiDepartment of Pathogen Biology, Shenyang Medical College, Shenyang, China.
Yanting LiDepartment of Pathogen Biology, Shenyang Medical College, Shenyang, China.
Chunmeng ZhangDepartment of Pathogen Biology, Shenyang Medical College, Shenyang, China.
Guangyan LiuDepartment of Pathogen Biology, Shenyang Medical College, Shenyang, China. liuguangyan@symc.edu.cn.
Shenyang Medical College · CN

Funding

Foundation of Liaoning Educational Committee LJKQZ2021176Innovation Fund of Shenyang Medical College Y20220508Natural Science Foundation of Liaoning Province of China 2022-MS-409Science and Technology Innovation Project of Shenyang RC210215
6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection is a noteworthy cause of liver diseases, especially cirrhosis and hepatocellular carcinomas. However, the interaction between the host and HBV has not been fully elucidated. Peptide YY (PYY) is a 36-amino-acid gastrointestinal hormone that is mainly involved in the regulation of the human digestive system. This study found that PYY expression was reduced in HBV-expressing hepatocytes and HBV patients. Overexpression of PYY could significantly inhibit HBV RNA, DNA levels, and the secretion of HBsAg. In addition, PYY inhibits HBV RNA dependent on transcription through reducing the activities of CP/Enh I/II, SP1 and SP2. Meanwhile, PYY blocks HBV replication independent on core, polymerase protein and ε structure of pregenomic RNA. These results suggest that PYY can impair HBV replication by suppressing viral promoters/enhancers in hepatocytes. Our data shed light on a novel role for PYY as anti-HBV restriction factor.

Indexed as

Hepatitis BLiver NeoplasmsHepatitis B Surface AntigensHepatitis B virusHumansPeptide YYRNAVirus ReplicationHepatitis B Surface AntigensPeptide YYRNAHBV promoters, enhancersHepatitis B virusPeptide YY

Identifiers

PMID37380814
OpenAlexW4382394308

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.