ArticleScientific reports2023
Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- Genome Evolution in Social Insects.Genome biology and evolution · 2026Review
- Isoform-resolved transcriptomics reveals stage-specific isoform switching and protein domain remodeling inTranscription · 2026Article
- Contrasting whole-genome diversity patterns and adaptation in honeybees from two southern European glacial refugia.iScience · 2026Article
- Article
- Analysis of molecular and cellular bases of honey bee mushroom body development.Scientific reports · 2025Article
- Identification, expression profiling and potential functional roles of nuclear receptors in the social aphid Pseudoregma bambucicola.BMC genomics · 2025Article
- Nuclear genome assembly of Leucinodes orbonalis (Lepidoptera: Crambidae) collected from the Philippines.Journal of insect science (Online) · 2025Article
- Interactions of juvenile hormone, 20-hydroxyecdysone, developmental genes, and miRNAs during pupal development in Apis mellifera.Scientific reports · 2025Article
- Unique spatially and temporary-regulated/sex-specific expression of a long ncRNA, Nb-1, suggesting its pleiotropic functions associated with honey bee lifecycle.Scientific reports · 2024Article
- The fecal microbiota from children with autism impact gut metabolism and learning and memory abilities of honeybees.Frontiers in microbiology · 2023Article
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5 authors at 1 institution in 1 country.
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Abstract
Ecdysone signaling plays central roles in morphogenesis and female ovarian development in holometabolous insects. In the European honey bee (Apis mellifera L.), however, ecdysone receptor (EcR) is expressed in the brains of adult workers, which have already undergone metamorphosis and are sterile with shrunken ovaries, during foraging behavior. Aiming at unveiling the significance of EcR signaling in the worker brain, we performed chromatin-immunoprecipitation sequencing of EcR to search for its target genes using the brains of nurse bees and foragers. The majority of the EcR targets were common between the nurse bee and forager brains and some of them were known ecdysone signaling-related genes. RNA-sequencing analysis revealed that some EcR target genes were upregulated in forager brains during foraging behavior and some were implicated in the repression of metabolic processes. Single-cell RNA-sequencing analysis revealed that EcR and its target genes were expressed mostly in neurons and partly in glial cells in the optic lobes of the forager brain. These findings suggest that in addition to its role during development, EcR transcriptionally represses metabolic processes during foraging behavior in the adult worker honey bee brain.
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