ArticleNature2023
Cancer aneuploidies are shaped primarily by effects on tumour fitness.
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In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
40.7field-weighted citation impact, top 1% of its field
What it found
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Who cites it
63 citing papers in PubMed, 102 citations in OpenAlex.
- Article
- LeafRank: A phylodynamic framework for inferring relative fitness from single-cell phylogenies in chromosomally unstable tumors.bioRxiv : the preprint server for biology · 2026Article
- Breast cancer genomic subtype-specific copy number alterations in metastases.Scientific reports · 2026Article
- A single chromosome 3p break initiates clear cell renal cell carcinoma evolution.bioRxiv : the preprint server for biology · 2026Article
- Low-input CSF cfDNA shallow whole-genome sequencing for CNV-based diagnosis and monitoring of leptomeningeal metastasis in lung cancer.Acta neuropathologica communications · 2026Article
- HOROSCOPE: Decoding human centromere architecture from short reads usingbioRxiv : the preprint server for biology · 2026Article
- Chromosome-arm-specific telomere length governs dual modes of structural genome evolution in IDH-mutant astrocytoma.bioRxiv : the preprint server for biology · 2026Article
- Impact of Chromosomal Instability and Aneuploidy in Cancer Development.Annual review of cancer biology · 2026Article
- Protein buffering of aneuploidy is driven by coordinated factors identified through machine learning.Molecular systems biology · 2026Article
- Chromosome length is constrained by spindle scaling to ensure faithful mitosis in mammals.Molecular systems biology · 2026Article
- Transient centrosome loss in cultured prostate epithelial cells induces chromosomal instability to produce an oncogenic genotype that correlates with poor clinical outcomes.British journal of cancer · 2026Article
- Integrative Genomic Profiling of Pediatric Solid Tumors Reveals Clinically Relevant Variants and Chromosomal Arm Aneuploidies Signatures.Cancer medicine · 2026Article
- PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer Cells.bioRxiv : the preprint server for biology · 2026Article
- Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer.Cancer discovery · 2026Article
- Pivotal role of biallelic frequency analysis in identifying copy number alterations using genome-wide methods in tumors with a high level of aneuploidy.Journal of applied genetics · 2026Article
- Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice.Science advances · 2026Article
- Pan-Cancer Analysis of WRN: From Multi-Omics Biomarker Discovery to Therapy-Guiding Functional Evidence.OncoTargets and therapy · 2026Article
- ALFA-K: Local adaptive mapping of karyotype fitness landscapes.Nature communications · 2025Article
- Recurrent somatic copy number alterations in resected cerebral cavernous malformations.Human genomics · 2025Article
- Divergent proteome tolerance against gain and loss of chromosome arms.Molecular cell · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 1 country.
Juliann ShihCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0002-4086-8651
Shahab SarmashghiCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Nadja Zhakula-KostadinovaDepartment of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0001-7205-230X
Shu ZhangCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Yohanna GeorgisDepartment of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Stephanie H HoytCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0003-2570-6838
Michael S CuocoDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Galen F GaoCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Liam F SpurrCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Ashton C BergerCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0001-5195-2528
Gavin HaCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0001-7578-7272
Veronica RendoCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Hui ShenDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
Matthew MeyersonCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0002-9133-8108
Andrew D CherniackCancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0003-0470-0111
Alison M Taylor *Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA. at3488@cumc.columbia.edu.ORCID 0000-0001-9341-535X
Rameen Beroukhim *Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA. rameen_beroukhim@dfci.harvard.edu.ORCID 0000-0001-6303-3609
Broad Institute · USColumbia University · USDana-Farber Cancer Institute · USVan Andel Institute · US
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MGenetic evolution of glioblastomas during radiation and temozolomide therapyR01CA188228 · NCI · DANA-FARBER CANCER INST · PI BEROUKHIM, RAMEEN, CHAKRAVARTI, ARNAB · 2015 to 2025
$6.9MSynthetic lethalities to cell cycle disruption in gliomaR01CA262462 · NCI · DANA-FARBER CANCER INST · PI RAMEEN BEROUKHIM, KEITH LLOYD LIGON · 2022 to 2026
$3.3MMYB family alterations in pediatric gliomasR01CA215489 · NCI · DANA-FARBER CANCER INST · PI BEROUKHIM, RAMEEN, LIGON, KEITH LLOYD · 2017 to 2021
$2.8MCharacterizing TP53 and PPM1D mutations as resistance drivers to radiation therapy in Diffuse Intrinsic Pontine GliomasR01CA219943 · NCI · BROAD INSTITUTE, INC. · PI BEROUKHIM, RAMEEN, LIGON, KEITH LLOYD · 2017 to 2021
$2.5MCenter for the comprehensive analysis of somatic copy-number alterations in cancerU24CA210978 · NCI · BROAD INSTITUTE, INC. · PI BEROUKHIM, RAMEEN, CHERNIACK, ANDREW DAVID · 2016 to 2020
$2.3MFunctional Understanding of Chromosome Arm AneuploidiesR35GM147287 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alison M. Taylor · 2022 to 2026
$2.0MCenter for the Comprehensive Analysis of Cancer Somatic Copy-Number Alterations, Rearrangements, and Long-Read Sequencing DataU24CA264029 · NCI · BROAD INSTITUTE, INC. · PI BEROUKHIM, RAMEEN, CHERNIACK, ANDREW DAVID · 2021 to 2025
$1.9MFunctional Approaches to Understanding Cancer Aneuploidy: Interrogating the Effects of Chromosome 3p DeletionK22CA237733 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TAYLOR, ALISON M. · 2020 to 2022
$577kNCI NIH HHS K22 CA237733NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA188228NCI NIH HHS R01 CA215489NCI NIH HHS R01 CA219943NCI NIH HHS R01 CA262462NCI NIH HHS U24 CA210978NCI NIH HHS U24 CA264029NIGMS NIH HHS R35 GM147287
Abstract
Aneuploidies-whole-chromosome or whole-arm imbalances-are the most prevalent alteration in cancer genomes
Indexed as
AneuploidyCell Transformation, NeoplasticNeoplasmsCell LineageCentromereChromosomes, Human, Pair 8DNA Copy Number VariationsGenes, Tumor SuppressorHumansOncogenesTelomereWerner Syndrome HelicaseWerner Syndrome HelicaseWRN protein, human
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.